Catalog No.
PHK59201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SRPK1 (Gln513-Ser655).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SRPK1, Serine/arginine-rich protein-specific kinase 1, SFRS protein kinase 1, SRSF protein kinase 1, SR-protein-specific kinase 1
Purification
Purified by antigen affinity column.
Accession
Q96SB4
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Role of Serine arginine protein kinase 1 and Minichromosome maintenance protein 2 in predicting epithelial ovarian cancer response to treatment and prognosis., PMID:38216547
Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion., PMID:37973660
SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer., PMID:37190199
Chimeric antibody targeting SRPK-1 in the treatment of non-small cell lung cancer by inhibiting growth, migration and invasion., PMID:28656224
The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain., PMID:27616424
Expression of SRPK1 in gliomas and its role in glioma cell lines viability., PMID:26738865
Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice., PMID:25993998
Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia., PMID:25151644
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells., PMID:24550521
In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1., PMID:23772390
SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity., PMID:23761094
Detection of elevated antibodies against SR protein kinase 1 in the serum of Alzheimer's disease patients., PMID:21794928
Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract., PMID:17188683
Serological identification of adult T-cell leukaemia-associated antigens., PMID:16042687
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation., PMID:12660167
Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases., PMID:12615332
Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway., PMID:12417631
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)., PMID:10196197
Fission yeast mitotic regulator Dsk1 is an SR protein-specific kinase., PMID:9488736
Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles., PMID:9446799
Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors., PMID:7526381
For research use only. Not for human or drug use.
