Catalog No.
PHK46001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PANX1 (Ser236-Gln274).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
MRS1, Pannexin-1, PANX1
Purification
Purified by antigen affinity column.
Accession
Q96RD7
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain., PMID:39892387
Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309., PMID:38780416
Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309., PMID:38168229
Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury., PMID:37821897
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence., PMID:37589139
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation., PMID:36037373
Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice., PMID:34639052
H2O2 gel bleaching induces cytotoxicity and pain conduction in dental pulp stem cells via intracellular reactive oxygen species on enamel/dentin disc., PMID:34506603
Extracellular ATP: A Feasible Target for Cancer Therapy., PMID:33212982
Developmental studies on the acquisition of perception conducting pathways via TRP channels in rat molar odontoblasts using immunohistochemistry and RT-qPCR., PMID:31848975
Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo., PMID:31669824
Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane., PMID:30814251
Pannexin 1 Channels Contribute to IL-1β Expression via NLRP3/Caspase-1 Inflammasome in Aspergillus Fumigatus Keratitis., PMID:30793631
Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function., PMID:29234270
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin., PMID:29145453
Pannexin channels increase propidium iodide permeability in frozen-thawed dog spermatozoa., PMID:28390472
Expression and localization of pannexin-1 and CALHM1 in porcine bladder and their involvement in modulating ATP release., PMID:28254749
Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways., PMID:27126275
Pannexin-1 channels show distinct morphology and no gap junction characteristics in mammalian cells., PMID:26386583
Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice., PMID:26109673
Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway., PMID:25917852
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells., PMID:25690012
Pannexin 2 protein expression is not restricted to the CNS., PMID:25505382
Amplification of human platelet activation by surface pannexin-1 channels., PMID:24655807
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice., PMID:23977027
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro., PMID:23737642
A comparative antibody analysis of pannexin1 expression in four rat brain regions reveals varying subcellular localizations., PMID:23390418
Pannexin1 stabilizes synaptic plasticity and is needed for learning., PMID:23284764
Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout., PMID:22965528
Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis., PMID:22947051
Expression of pannexin isoforms in the systemic murine arterial network., PMID:22739252
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel., PMID:22159995
Targeting pannexin1 improves seizure outcome., PMID:21949881
Regulation by P2X7: epithelial migration and stromal organization in the cornea., PMID:18502993
Pannexin1 is expressed by neurons and glia but does not form functional gap junctions., PMID:17009242
For research use only. Not for human or drug use.
