Anti-Human NFATC2 Polyclonal Antibody

Catalog No.

PHG54501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NFATC2 (Ser407-Asn565).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, T-cell transcription factor NFAT1, NFATC2, NF-ATp, NFAT1, NFATP

Purification

Purified by antigen affinity column.

Accession

Q13469

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity., PMID:39850568

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia., PMID:39512835

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Antagonism of m3 Alleviates Type 2 Inflammation in Allergic Rhinitis Mice., PMID:36343939

Zizania latifolia and Its Major Compound Tricin Regulate Immune Responses in OVA-Treated Mice., PMID:35807220

Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores., PMID:34884902

Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle., PMID:34752468

Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer., PMID:33707423

Confirmation of NKX3-1 Expression in EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma Using Monoclonal Antibody Immunohistochemistry, RT-PCR, and RNA In Situ Hybridization., PMID:33443863

The effect and associated mechanism of action of phosphodiesterase 4 (PDE4) inhibitor on CD4+ lymphocyte proliferation., PMID:33043479

Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice., PMID:32931581

The elevated serum levels of calcineurin and nuclear factor of activated T-cells 1 in children with Kawasaki disease., PMID:32183825

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline., PMID:32045592

Toll-like receptor 7 agonist imiquimod prevents the progression of SLE in MRL/lpr mice via inhibiting the differentiation of T follicular helper cells., PMID:32007709

Bisphenol A triggers the malignancy of acute myeloid leukemia cells via regulation of IL-4 and IL-6., PMID:31714645

Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway., PMID:31500188

Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis., PMID:31356622

Kawasaki disease OX40-OX40L axis acts as an upstream regulator of NFAT signaling pathway., PMID:30723312

Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism., PMID:29969451

PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours., PMID:29920735

[Ewing sarcomas and Ewing-like sarcomas : New aspects]., PMID:29480450

The Transcription Factor NFAT1 Participates in the Induction of CD4+ T Cell Functional Exhaustion during Plasmodium yoelii Infection., PMID:28630062

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection., PMID:28530712

Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling., PMID:28359080

Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy., PMID:28183531

[SOI-nanowire biosensor for the detection of D-NFAT 1 protein]., PMID:26350736

Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity., PMID:25745993

Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment., PMID:25201034

6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation., PMID:25114106

Impaired T cell activation and cytokine production by calcitriol-primed human B cells., PMID:24965738

NFAT1 transcription factor in dendritic cells is required to modulate T helper cell differentiation., PMID:24894426

FGF2 activates TRPC and Ca(2+) signaling leading to satellite cell activation., PMID:24575047

NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells., PMID:24507801

Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease., PMID:24325470

Immunologic features of Cornelia de Lange syndrome., PMID:23821697

Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease., PMID:23475901

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes., PMID:22989874

Three-way translocation (X;20;16)(p11;q13;q23) in essential thrombocythemia implicates NFATC2 in dysregulation of CSF2 expression and megakaryocyte proliferation., PMID:22911897

Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma., PMID:22766791

Increased immunosuppressive function of CD4(+)CD25(+)Foxp3(+)GITR+ T regulatory cells from NFATc2((-/-)) mice controls allergen-induced experimental asthma., PMID:22317750

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes., PMID:21474694

GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells., PMID:20368097

A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo., PMID:20007805

NFATc2 Ser170 phosphorylation marks mitosis in development and ES cells., PMID:19395856

CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production., PMID:19036925

Mechanical lesion activates newly identified NFATc1 in primary astrocytes: implication of ATP and purinergic receptors., PMID:18445232

Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro., PMID:18250226

Novel mutations in a Japanese patient with CD19 deficiency., PMID:17882224

NFAT in lymphocytes: a factor for all events?, PMID:17684296

Involvement of NFAT1 in B cell self-tolerance., PMID:16849457

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