Anti-Human PDE4D Polyclonal Antibody

Catalog No.

PHG17001

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PDE4D (Glu391-Thr711).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4D, PDE43, PDE4D, DPDE3

Purification

Purified by antigen affinity column.

Accession

Q08499

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Genetic polymorphisms to identify patients with an optimal response to tildrakizumab in psoriasis patients from real-life clinical practice., PMID:39081053

Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review., PMID:37924462

HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC., PMID:36732510

Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive., PMID:30485936

Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block., PMID:28626076

Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy., PMID:26792343

PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells., PMID:25524737

Effects of PDE4 pathway inhibition in rat experimental stroke., PMID:25224348

Defining the phosphodiesterase superfamily members in rat brain microvessels., PMID:22860158

PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance., PMID:22723333

Identification of new signaling components in the sensory epithelium of human saccule., PMID:21886636

Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland., PMID:19620657

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release., PMID:19371330

AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa., PMID:16177223

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue., PMID:15717866

Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey., PMID:11716814

Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects., PMID:11429397

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase., PMID:11134006

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain., PMID:10391907

Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis., PMID:10218983

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect., PMID:10213096

Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene., PMID:9677395

Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain., PMID:9443929

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B., PMID:8632354

Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists., PMID:7559525

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3., PMID:7476886

Characterization of a hormone-inducible, high affinity adenosine 3'-5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell., PMID:7794911

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