Anti-Human STUB1 Polyclonal Antibody

Catalog No.

PHK42801

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human STUB1 (Ser23-Tyr303).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Antigen NY-CO-7, CHIP, CLL-associated antigen KW-8, STUB1, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1, E3 ubiquitin-protein ligase CHIP, RING-type E3 ubiquitin transferase CHIP

Purification

Purified by antigen affinity column.

Accession

Q9UNE7

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions., PMID:40463190

Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms., PMID:39863102

O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer., PMID:39446384

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP., PMID:39266525

Peptide Degrader-Based Targeting of METTL3/14 Improves Immunotherapy Response in Cutaneous Melanoma., PMID:39136347

GABA/baclofen stabilizes PD-L1 and enhances immunotherapy of breast cancer., PMID:38601585

CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation., PMID:34905731

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma., PMID:34489334

CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation., PMID:34439093

Chaperone-assisted selective autophagy in healthy and papillomavirus-associated neoplastic urothelium of cattle., PMID:29981700

Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer., PMID:29326975

CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models., PMID:27178152

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates., PMID:27163177

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I., PMID:26695369

Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays., PMID:26370624

A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint., PMID:25990958

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer., PMID:22535373

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression., PMID:22407479

Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis., PMID:21272160

C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress., PMID:20677910

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo., PMID:16207874

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase., PMID:15466472

ErbB2 degradation mediated by the co-chaperone protein CHIP., PMID:12574167

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Anti-Human STUB1 Polyclonal Antibody.pdf