Catalog No.
PHE12701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GCK (Met1-Gln465).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Hexokinase-4, Hexokinase type IV, HK4, HK IV, Glucokinase, Hexokinase-D, GCK
Purification
Purified by antigen affinity column.
Accession
P35557
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
[TYPE 1 DIABETES MELLITUS AND MONOGENIC DIABETES - CAN THE TWO WALK TOGETHER?]., PMID:40413587
Genotype, Phenotype, and Clinical Characteristics of Maturity-onset Diabetes of the Young (MODY): Predominance of GCK-MODY., PMID:40338033
[Clinical characteristics and genetic analysis of maturity-onset diabetes of the young type 2 diagnosed in childhood]., PMID:39825658
SARS-CoV-2 cross-sectional serosurvey across three HIV-1 therapeutic clinical trials in Africa., PMID:39576151
Molecular and clinical profiles of pediatric monogenic diabetes subtypes: comprehensive genetic analysis of 138 patients., PMID:39504571
Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection., PMID:39427422
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity., PMID:39364395
Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells., PMID:39214097
VARIATIONS IN MONOGENIC DIABETES AND DIABETES SUSCEPTIBILITY GENES IN PEDIATRIC CASES: SINGLE CENTER EXPERIENCE., PMID:38933241
Development of a clinical calculator to aid the identification of MODY in pediatric patients at the time of diabetes diagnosis., PMID:38719926
Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship., PMID:38665000
Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414
Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China., PMID:36723869
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register., PMID:36418577
AZD7442 (Tixagevimab/Cilgavimab) for Post-Exposure Prophylaxis of Symptomatic Coronavirus Disease 2019., PMID:36411267
Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran., PMID:36100423
Identification of Variants Responsible for Monogenic Forms of Diabetes in Brazil., PMID:35592779
Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19., PMID:35443106
Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population., PMID:34888019
Next- generation sequencing is an effective method for diagnosing patients with different forms of monogenic diabetes., PMID:34826540
Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age., PMID:34746319
A novel mutation in GCK gene: Beware of SGA child with diabetic mother., PMID:34627944
Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar., PMID:34101350
A Clinical Prediction Model to Distinguish Maturity-Onset Diabetes of the Young From Type 1 and Type 2 Diabetes in the Chinese Population., PMID:33991656
Gemtuzumab-Ozogamicin-Related Impaired Hemoglobin-Haptoglobin Scavenging as On-Target/Off-Tumor Toxicity of Anti-CD33 AML Therapy: A Report of Two Cases., PMID:33824768
Clinical and laboratory clues of maturity-onset diabetes of the young and determination of association with molecular diagnosis., PMID:32710514
Update on clinical screening of maturity-onset diabetes of the young (MODY)., PMID:32528556
Detection and analysis of glucose metabolism-related genes in childhood diabetes using targeted next-generation sequencing: In pediatric population-a hospital-based study., PMID:32266039
Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection., PMID:32128257
Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy., PMID:32086287
Hyperglycemia in pediatric age: could it be maturity onset diabetes of the young? Case reports and review of the literature., PMID:31905448
Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study., PMID:31704690
Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population., PMID:31276222
[Hyperglycemia caused by mutation of GCK gene in 10 patients analysis of clinical and mutation characteristics]., PMID:31216801
An evolving spectrum of diabetes in a woman with GCK-MODY., PMID:30608898
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
Temporal dynamics of serum let-7g expression mirror the decline of residual beta-cell function in longitudinal observation of children with type 1 diabetes., PMID:30259606
More than kin, less than kind: one family and the many faces of diabetes in youth., PMID:29412391
Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?, PMID:29355436
The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience., PMID:29175806
Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes., PMID:28597946
Dysmorphic Features, Frontal Cerebral Cavernoma, and Hyperglycemia in a Girl with a De Novo Deletion of 7.23 Mb in Region 7p13-p12.1., PMID:28387648
Monogenic Diabetes Accounts for 6.3% of Cases Referred to 15 Italian Pediatric Diabetes Centers During 2007 to 2012., PMID:28323911
Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849
[A rare cause of diabetes mellitus]., PMID:27404933
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population., PMID:27167055
MAP4K Family Kinases in Immunity and Inflammation., PMID:26791862
[Humoral response markers in GCK MODY]., PMID:28633158
Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection., PMID:26124093
For research use only. Not for human or drug use.
