Anti-Human PMEL Polyclonal Antibody

Catalog No.

PHE28701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PMEL (Gln65-Thr299).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen

Purification

Purified by antigen affinity column.

Accession

P40967

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors., PMID:39805660

[Clinicopathological features of metastatic melanoma in effusion cytology of serosal cavity]., PMID:39103266

In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1)., PMID:39008470

PRAME and Historical Immunohistochemical Antibodies Ki-67, P16, and HMB-45 in Ambiguous Melanocytic Tumors., PMID:38916203

β-Catenin in Dendritic Cells Negatively Regulates CD8 T Cell Immune Responses through the Immune Checkpoint Molecule Tim-3., PMID:38793711

Requirements for anti-aquaporin 5 autoantibody production in a mouse model., PMID:37718989

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441

Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo., PMID:34854998

CCL17-CCR4 axis contributes to the onset of vitiligo in mice., PMID:34077992

Dry Formulation of Virus-Like Particles in Electrospun Nanofibers., PMID:33802376

Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report., PMID:33327228

Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice., PMID:33084421

Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes., PMID:32817208

Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis., PMID:32668786

SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint., PMID:32122464

CD10 and p63 expression in a sarcomatoid undifferentiated melanoma: A cautionary (and molecularly annotated) tale., PMID:31943331

PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa)., PMID:31851063

Optimizing T-cell receptor avidity with somatic hypermutation., PMID:31381134

Utility of p16-Ki-67-HMB45 score in sorting benign from malignant Spitz tumors., PMID:31351802

ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation., PMID:29940187

Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver., PMID:29122287

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment., PMID:28851824

Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures., PMID:28288506

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas., PMID:28123877

Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin., PMID:27497917

Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects., PMID:27267778

Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection., PMID:27193292

Hashimoto's thyroiditis could be secondary to vitiligo: the possibility of antigen crossover and oxidative stress between the two diseases., PMID:27020052

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma., PMID:25787767

Metastatic melanoma of the tongue: a case report with immunohistochemical profile., PMID:25427453

Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763

Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965

Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest., PMID:25127875

A monoclonal antibody against PMEL., PMID:25118787

Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility., PMID:25038199

Marginal and joint distributions of S100, HMB-45, and Melan-A across a large series of cutaneous melanomas., PMID:23899062

Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update., PMID:23648379

[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]., PMID:23643172

A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity., PMID:23333935

Metastatic melanoma presenting as an isolated breast tumor: a study of 20 cases with emphasis on several primary mimickers., PMID:23276173

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy., PMID:22972494

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma., PMID:22613716

Perivascular epithelioid cell tumor (PEComa) of gynecologic origin: a clinicopathological study of three cases., PMID:22439417

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin., PMID:22297636

Aberrant expression of HMB-45 in traumatized melanocytic nevi., PMID:22285619

Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome., PMID:22158488

Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America., PMID:22143732

The use of immunocytochemical study in the cytologic diagnosis of melanoma: evaluation of three antibodies., PMID:22021247

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis., PMID:21962903

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer., PMID:20631075

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