Anti-Human CDC25C Polyclonal Antibody

Catalog No.

PHD88501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDC25C (Thr268-Pro473).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C

Purification

Purified by antigen affinity column.

Accession

P30307

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

A multicenter, randomized phase 2 study to establish combinations of CBP501, cisplatin and nivolumab for ≥3rd-line treatment of patients with advanced pancreatic adenocarcinoma., PMID:38422585

Anti-hepatoma Effect of DC2.4 Cells Transfected with Tumor-Associated Antigen Cdc25C In Vitro., PMID:35292875

The Suppressing Effects of Dkk3 Expression on Aggressiveness and Tumorigenesis of Colorectal Cancer., PMID:33425757

Bevacizumab Augments the Antitumor Efficacy of Infigratinib in Hepatocellular Carcinoma., PMID:33321903

Heme oxygenase-1 attenuates seawater drowning-induced acute lung injury through a reduction in inflammation and oxidative stress., PMID:31254959

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin., PMID:28335434

JNK does not regulate meiotic progression in Xenopus oocytes: The strange case of pJNK and pERK., PMID:27297883

A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition., PMID:27134571

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells., PMID:26683224

A novel derivative of quinazoline, WYK431 induces G2/M phase arrest and apoptosis in human gastric cancer BGC823 cells through the PI3K/Akt pathway., PMID:24859921

Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells., PMID:23707954

TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis., PMID:23456551

CHK1 kinase activity assay., PMID:22941630

Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts., PMID:22834967

Multiple signal transduction pathways are involved in G2/M growth arrest and apoptosis induced by the immunomodulator AS101 in multiple myeloma., PMID:22712839

Novel therapies in phase II and III trials for malignant pleural mesothelioma., PMID:22223868

Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells., PMID:21617228

KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer., PMID:21509526

Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells., PMID:20668692

Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C., PMID:20530684

Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes., PMID:20500813

JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint., PMID:20220133

Dissecting the M phase-specific phosphorylation of serine-proline or threonine-proline motifs., PMID:20219976

Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen., PMID:20085455

Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent., PMID:18957056

Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells., PMID:18585839

MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells., PMID:18491135

Mechanism of cell death induced by cis-3, 4', 5-trimethoxy-3'-aminostilbene in ovarian cancer., PMID:18433847

Differential phosphorylation of Cdc25C phosphatase in mitosis., PMID:18384749

Polo-box domains confer target specificity to the Polo-like kinase family., PMID:18359294

Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway., PMID:17273739

Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway., PMID:17129359

Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells., PMID:15961392

Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue., PMID:15567944

Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells., PMID:15471901

Timing of Plk1 and MPF activation during porcine oocyte maturation., PMID:15278898

CHK1 kinase activity assay., PMID:15220526

The polo box is required for multiple functions of Plx1 in mitosis., PMID:15016807

SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c., PMID:12742231

Redox regulation of Cdc25C., PMID:11925443

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage., PMID:11836499

Acquisition of meiotic competence in mouse oocytes: absolute amounts of p34(cdc2), cyclin B1, cdc25C, and wee1 in meiotically incompetent and competent oocytes., PMID:11090427

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity., PMID:10744722

The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes., PMID:10590085

A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevis., PMID:10433828

Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site., PMID:10330186

Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes., PMID:10068474

Production and characterization of a rabbit monoclonal antibody against human CDC25C phosphatase., PMID:9790074

The cdc25B phosphatase is essential for the G2/M phase transition in human cells., PMID:9683638

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53., PMID:9679054

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