Catalog No.
PHD48501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SDHB (Arg38-Val280).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Ip, SDH1, SDHB, Iron-sulfur subunit of complex II, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, SDH
Purification
Purified by antigen affinity column.
Accession
P21912
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Succinate dehydrogenase deficient renal cell carcinoma frequently expresses GATA3 and L1CAM., PMID:40100385
Gastrointestinal Stromal Tumors: Variants and Some Pitfalls That They Create., PMID:39466697
Comprehensive Genomic Assessment of Advanced-Stage GI Stromal Tumors Using the Japanese National Center for Cancer Genomics and Advanced Therapeutics Database., PMID:39447098
Loss of cholinergic receptor muscarinic 1 impairs cortical mitochondrial structure and function: implications in Alzheimer's disease., PMID:37274741
PD-L1 expression and association with genetic background in pheochromocytoma and paraganglioma., PMID:36439433
Cauda equina neuroendocrine tumors show biological features distinct from other paragangliomas and visceral neuroendocrine tumors., PMID:36348031
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas., PMID:36178902
Deep Membrane Proteome Profiling Reveals Overexpression of Prostate-Specific Membrane Antigen (PSMA) in High-Risk Human Paraganglioma and Pheochromocytoma, Suggesting New Theranostic Opportunity., PMID:34770976
Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma., PMID:34638246
Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1., PMID:34531523
LncRNA expression and SDHB mutations in pheochromocytomas and paragangliomas., PMID:34461576
Immunoexpression of SDHB, FH, and CK20 among eosinophilic renal tumors: A tissue microarray study., PMID:34246177
Case Report: Primary Hypothyroidism Associated With Lutetium 177-DOTATATE Therapy for Metastatic Paraganglioma., PMID:33551992
Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells., PMID:31150687
Papillary renal cell carcinoma with cytologic and molecular genetic features overlapping with renal oncocytoma: Analysis of 10 cases., PMID:30072012
Implication of SPARC in the modulation of the extracellular matrix and mitochondrial function in muscle cells., PMID:29420632
Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute., PMID:29196263
Renal cell carcinoma with angioleiomyoma-like stroma and clear cell papillary renal cell carcinoma: exploring SDHB protein immunohistochemistry and the relationship to tuberous sclerosis complex., PMID:29180251
Succinate Dehydrogenase B (SDHB) Immunohistochemistry for the Evaluation of Muscle Biopsies., PMID:27556822
Use of monoclonal antibodies to detect specific mutations in formalin-fixed, paraffin-embedded tissue sections., PMID:27083401
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells., PMID:26101719
An immunohistochemical study of potential diagnostic and therapeutic biomarkers of wild-type gastrointestinal stromal tumours., PMID:25659413
Oncotargets in different renal cancer subtypes., PMID:25619751
Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas., PMID:25554089
SDHD immunohistochemistry: a new tool to validate SDHx mutations in pheochromocytoma/paraganglioma., PMID:25405498
Adrenocortical oncocytoma presenting as Cushing's syndrome: an additional report of a paediatric case., PMID:25077961
Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?, PMID:25048361
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma., PMID:25034258
Usefulness of Succinate dehydrogenase B (SDHB) immunohistochemistry in guiding mutational screening among patients with pheochromocytoma-paraganglioma syndromes., PMID:24735130
Contributions of molecular analysis to the diagnosis and treatment of gastrointestinal neoplasms., PMID:24342289
Signalling pathways in succinate dehydrogenase B-associated renal carcinoma., PMID:24236567
Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling., PMID:23955600
Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation., PMID:23282968
Common genetic mutations in the start codon of the SDH subunit D gene among Chinese families with familial head and neck paragangliomas., PMID:21945342
[SDHB expression in Warthin's tumour]., PMID:21561594
Specific electron transport chain abnormalities in amyotrophic lateral sclerosis., PMID:19240958
Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria., PMID:17899367
A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia., PMID:17487275
Cloning and expression in Escherichia coli of sdhA, the structural gene for cytochrome b558 of the Bacillus subtilis succinate dehydrogenase complex., PMID:2987185
For research use only. Not for human or drug use.
