Catalog No.
PHH33601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PDK4 (Ser10-Met411).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, IF: 1:50-1:100, WB: 1:1000-1:4000
Target
PDHK4, Pyruvate dehydrogenase kinase isoform 4, PDK4, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Purification
Purified by antigen affinity column.
Accession
Q16654
Applications
ELISA, IHC, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the "Smart" exosome nanoparticle therapy., PMID:39004737
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy., PMID:38664790
Mitochondrial bioenergetics in ocular fibroblasts of two myasthenia gravis cases., PMID:35746973
Pyruvate dehydrogenase kinase 4-mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B-cell lymphoma by affecting the expression of MS4A1/CD20., PMID:34252986
Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes., PMID:33424774
PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia., PMID:30894018
Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis., PMID:31815032
Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ., PMID:29056962
Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension., PMID:27456128
Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3., PMID:26747726
Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy., PMID:24861054
Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis., PMID:24293610
[Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions]., PMID:17202796
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal., PMID:11842126
Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion., PMID:11723055
Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation., PMID:11054649
Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding., PMID:10905486
Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression., PMID:10698691
For research use only. Not for human or drug use.
