Catalog No.
PMC77901
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse GLI2 (Glu416-Gly570).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Zinc finger protein GLI2, Tax helper protein, Gli2, Thp
Purification
Purified by antigen affinity column.
Accession
Q0VGT2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Epigenetic Effects of Resveratrol on Oncogenic Signaling in Breast Cancer., PMID:38474826
LMCD1 antisense RNA 1 is a newly identified long noncoding RNA., PMID:34232945
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation., PMID:34062094
New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis., PMID:30982371
Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway., PMID:30864728
Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer., PMID:30647844
Regulation of Gli2 stability by deubiquitinase OTUB2., PMID:30241937
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse., PMID:29487109
Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837
Endometrial stem cell-derived granulocyte-colony stimulating factor attenuates endometrial fibrosis via sonic hedgehog transcriptional activator Gli2., PMID:29329377
Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling., PMID:29221447
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant., PMID:28673820
Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328
Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells., PMID:28144905
Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro., PMID:27841005
Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway., PMID:26718029
Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells., PMID:26238488
Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR., PMID:26179041
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667
A de novo 10.79 Mb interstitial deletion at 2q13q14.2 involving PAX8 causing hypothyroidism and mullerian agenesis: a novel case report and literature review., PMID:25484916
GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis., PMID:25432075
Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features., PMID:25296932
Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice., PMID:24450438
Sonic hedgehog pathway dysregulation in skin basal-cell carcinoma of a Polish population., PMID:24203628
Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells., PMID:24086482
Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma., PMID:23835807
The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents., PMID:23792444
Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy., PMID:23762415
NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200., PMID:23482671
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling., PMID:23166838
Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion., PMID:23028941
Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis., PMID:22949932
Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation., PMID:22771389
Neuron precursor features of spindle cell oncocytoma of adenohypophysis., PMID:22585606
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function., PMID:21664576
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment., PMID:21454528
Sonic hedgehog stimulates proliferation of human periodontal ligament stem cells., PMID:21441223
Bone structural components regulating sites of tumor metastasis., PMID:21424744
Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst., PMID:20801488
Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor., PMID:20371205
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation., PMID:20154143
Canonical Wnt signaling regulates Foxc1/2 expression in P19 cells., PMID:19782461
Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein., PMID:19759178
Expression of hedgehog signaling molecules in Merkel cell carcinoma., PMID:19644931
Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium., PMID:19432668
Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells., PMID:19245435
Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas., PMID:19200615