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Anti-Mouse GLI2 Polyclonal Antibody

Catalog #:   PMC77901 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q0VGT2
Overview

Catalog No.

PMC77901

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse GLI2 (Glu416-Gly570).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Zinc finger protein GLI2, Tax helper protein, Gli2, Thp

Purification

Purified by antigen affinity column.

Accession

Q0VGT2

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN-BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with GLI2 antibody (PMC77901) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 21 kDa
    Observed MW: 21 kDa
References

Epigenetic Effects of Resveratrol on Oncogenic Signaling in Breast Cancer., PMID:38474826

LMCD1 antisense RNA 1 is a newly identified long noncoding RNA., PMID:34232945

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation., PMID:34062094

New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413

The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis., PMID:30982371

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway., PMID:30864728

Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer., PMID:30647844

Regulation of Gli2 stability by deubiquitinase OTUB2., PMID:30241937

Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169

Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse., PMID:29487109

Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837

Endometrial stem cell-derived granulocyte-colony stimulating factor attenuates endometrial fibrosis via sonic hedgehog transcriptional activator Gli2., PMID:29329377

Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling., PMID:29221447

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478

PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant., PMID:28673820

Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells., PMID:28144905

Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro., PMID:27841005

Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway., PMID:26718029

Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells., PMID:26238488

Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR., PMID:26179041

Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667

A de novo 10.79 Mb interstitial deletion at 2q13q14.2 involving PAX8 causing hypothyroidism and mullerian agenesis: a novel case report and literature review., PMID:25484916

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis., PMID:25432075

Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features., PMID:25296932

Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice., PMID:24450438

Sonic hedgehog pathway dysregulation in skin basal-cell carcinoma of a Polish population., PMID:24203628

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells., PMID:24086482

Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma., PMID:23835807

The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents., PMID:23792444

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy., PMID:23762415

NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200., PMID:23482671

Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling., PMID:23166838

Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion., PMID:23028941

Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis., PMID:22949932

Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation., PMID:22771389

Neuron precursor features of spindle cell oncocytoma of adenohypophysis., PMID:22585606

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function., PMID:21664576

GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment., PMID:21454528

Sonic hedgehog stimulates proliferation of human periodontal ligament stem cells., PMID:21441223

Bone structural components regulating sites of tumor metastasis., PMID:21424744

Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst., PMID:20801488

Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor., PMID:20371205

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation., PMID:20154143

Canonical Wnt signaling regulates Foxc1/2 expression in P19 cells., PMID:19782461

Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein., PMID:19759178

Expression of hedgehog signaling molecules in Merkel cell carcinoma., PMID:19644931

Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium., PMID:19432668

Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells., PMID:19245435

Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas., PMID:19200615

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-Mouse GLI2 Polyclonal Antibody [PMC77901]
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