Catalog No.
PHK37301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PPARGC1A (Ser636-Arg798).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1
Purification
Purified by antigen affinity column.
Accession
Q9UBK2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity., PMID:39631851
SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cells., PMID:38721826
Predictive value of a stemness-based classifier for prognosis and immunotherapy response of hepatocellular carcinoma based on bioinformatics and machine-learning strategies., PMID:38694506
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice., PMID:34763039
Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice., PMID:34537761
Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis., PMID:33915296
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells., PMID:33806766
PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10-mediated anti-inflammatory response., PMID:32633848
Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells., PMID:32591623
Sitagliptin improves functional recovery via GLP-1R-induced anti-apoptosis and facilitation of axonal regeneration after spinal cord injury., PMID:32573108
β1 adrenoceptor antibodies induce myocardial apoptosis via inhibiting PGC-1α-related pathway., PMID:32503464
CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs., PMID:32209473
Array-based Western-blotting reveals spatial differences in hepatic signaling and metabolism following CAR activation., PMID:32123963
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases., PMID:32102312
PGC-1α activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer., PMID:31451071
Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells., PMID:31150687
Renal PGC1α May Be Associated with Recovery after Delayed Graft Function., PMID:29268263
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death., PMID:28969371
Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells., PMID:28898431
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction., PMID:28436957
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity., PMID:28096382
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion., PMID:27496729
Out of the TWEAKlight: Elucidating the Role of Fn14 and TWEAK in Acute Kidney Injury., PMID:27339384
The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury., PMID:26535995
αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium., PMID:26244551
Intravitreally Injected Anti-VEGF Antibody Reduces Brown Fat in Neonatal Mice., PMID:26226015
AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle., PMID:25887856
Tumour necrosis factor-α promotes liver ischaemia-reperfusion injury through the PGC-1α/Mfn2 pathway., PMID:24898700
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise., PMID:24644429
Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis., PMID:24293610
Sequential signaling cascade of IL-6 and PGC-1α is involved in high glucose-induced podocyte loss and growth arrest., PMID:23692924
Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo., PMID:23166610
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN., PMID:23150719
Analyzing phosphorylation-dependent regulation of subcellular localization and transcriptional activity of transcriptional coactivator NT-PGC-1α., PMID:23100231
Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance., PMID:23070475
Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain., PMID:22878646
Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease., PMID:22633948
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1., PMID:22174314
PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells., PMID:21817823
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling., PMID:21723505
Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis., PMID:21059926
WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration., PMID:20870744
Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle., PMID:18775884
Persistence of regenerative myogenesis in spite of down-regulation of activity-dependent genes in long-term denervated rat muscle., PMID:18397613
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) upregulated E-cadherin expression in HepG2 cells., PMID:18242180
Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits., PMID:18222924
Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury., PMID:17593537
Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro., PMID:17467307
Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain., PMID:17335037
For research use only. Not for human or drug use.
