Catalog No.
PHK37101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human BBC3 (Glu130-Pro180).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
p53 up-regulated modulator of apoptosis, BBC3, JFY-1, PUMA, Bcl-2-binding component 3, isoforms 1/2
Purification
Purified by antigen affinity column.
Accession
Q9BXH1
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer., PMID:35135489
Association Between DNA Damage Response, Fibrosis and Type I Interferon Signature in Systemic Sclerosis., PMID:33123169
Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway., PMID:31182761
Bendamustine alone or with rituximab modifies expression of apoptosis-regulating genes and proteins of CLL cells, depending on IGVH mutational status., PMID:30187811
MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct., PMID:30088967
Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer., PMID:29755130
CTCF knockout reveals an essential role for this protein during the zebrafish development., PMID:29723654
Treatment of Donor Rat Hearts Prior to Transplantation with FLIP (FADD-Like Interleukin Beta-Converting Enzyme (FLICE)-Like Inhibitory Protein) in Cardioplegic Solution Decreased Apoptosis at Thirty Minutes Post-transplantation and Decreased Total Tyrosine Phosphorylation Levels., PMID:29483486
Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α., PMID:28406729
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells., PMID:27737950
β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis., PMID:25354317
Embryonic exposure to carbendazim induces the transcription of genes related to apoptosis, immunotoxicity and endocrine disruption in zebrafish (Danio rerio)., PMID:25304545
PUMA regulates germ cell loss and primordial follicle endowment in mice., PMID:24859845
Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia., PMID:24117128
The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells., PMID:23517560
Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association., PMID:23139272
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation., PMID:22964580
Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells., PMID:22946656
Regulation of PUMA induced by mechanical stress in rat cardiomyocytes., PMID:22862895
Hyperthermia-enhanced TRAIL- and mapatumumab-induced apoptotic death is mediated through mitochondria in human colon cancer cells., PMID:22174016
Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells., PMID:22021910
Regulation of memory B-cell survival by the BH3-only protein Puma., PMID:21868573
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas., PMID:21492126
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice., PMID:21490394
Valsartan protects against ER stress-induced myocardial apoptosis via CHOP/Puma signaling pathway in streptozotocin-induced diabetic rats., PMID:21345370
PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells., PMID:19421143
Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms., PMID:19261878
Immunohistochemical detection of BH3-only proteins in ameloblastic tumors., PMID:18826384
Involvement of p53-transactivated Puma in cisplatin-induced renal tubular cell death., PMID:18761355
Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family., PMID:18343378
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance., PMID:17486061
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis., PMID:17380123
The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells., PMID:16940052
Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1., PMID:16007132
Two different adenylyl cyclases in brain distinguished by monoclonal antibodies., PMID:3338465
For research use only. Not for human or drug use.
