Catalog No.
PHK36601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SIRT3 (Lys122-Lys399).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial, SIR2-like protein 3, SIRT3, Regulatory protein SIR2 homolog 3, SIR2L3, hSIRT3
Purification
Purified by antigen affinity column.
Accession
Q9NTG7
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer., PMID:40252727
The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential., PMID:40142268
Possible pathogenic mechanisms for doxorubicin-induced splenic atrophy in a human breast cancer xenograft mouse model., PMID:38943348
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis., PMID:37993768
Parkinson's disease neurons exhibit alterations in mitochondrial quality control proteins., PMID:37553379
NAD+ supplementation improves mAb productivity in CHO cells via a glucose metabolic shift., PMID:36717516
17β-estradiol suppresses H2O2-induced senescence in human umbilical vein endothelial cells by inducing autophagy through the PVT1/miR-31/SIRT3 axis., PMID:36584773
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3., PMID:35393905
Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3., PMID:34769322
Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice., PMID:32865093
Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition., PMID:32463172
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells., PMID:32306906
17β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy., PMID:32172411
Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse., PMID:32068790
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase., PMID:31677030
Stimulation of Na+/K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPK/SIRT3/PPARγ Signaling Pathway., PMID:31636805
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions., PMID:30774023
Correction: Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia., PMID:29930768
Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice., PMID:29581157
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation., PMID:29277324
AGEs Decreased SIRT3 Expression and SIRT3 Activation Protected AGEs-Induced EPCs' Dysfunction and Strengthened Anti-oxidant Capacity., PMID:28032248
Post-translational modification by acetylation regulates the mitochondrial carnitine/acylcarnitine transport protein., PMID:27864727
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy., PMID:27423420
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia., PMID:27270321
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells., PMID:26912655
Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage., PMID:26473372
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients., PMID:26121130
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells., PMID:25152236
Mitochondrial acetylation and genetic models of Parkinson's disease., PMID:25149217
Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN., PMID:24669285
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development., PMID:24370889
Ethanol metabolism modifies hepatic protein acylation in mice., PMID:24073283
Cyclophilin D modulates mitochondrial acetylome., PMID:24062335
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation., PMID:23835326
Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis., PMID:23710283
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity., PMID:23159776
Non-histone lysine acetylated proteins in heart failure., PMID:22155497
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation., PMID:21639917
Mechanism-based affinity capture of sirtuins., PMID:21184005
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress., PMID:17437997
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases., PMID:16790548
For research use only. Not for human or drug use.
