Catalog No.
PHK13201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NEU3/Sialidase-3 (Met1-Asn428).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
N-acetyl-alpha-neuraminidase 3, NEU3, Sialidase-3, Ganglioside sialidasedis, Membrane sialidase
Purification
Purified by antigen affinity column.
Accession
Q9UQ49
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Analysis of Brain Lipids in the Early-Onset Tay-Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3., PMID:36003081
Neuraminidase Inhibitor Zanamivir Ameliorates Collagen-Induced Arthritis., PMID:33572654
Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines., PMID:33233823
Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer., PMID:31268153
α-2,3-Sialyltransferase 1 and neuraminidase-3 from monocytes in patients with rheumatoid arthritis correlate with disease activity measures: A pilot study., PMID:30913115
Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells., PMID:29357434
Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited., PMID:28655817
Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study., PMID:26981635
NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels., PMID:25922362
Phosphatidic acid-mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration., PMID:25678627
Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum., PMID:25652216
Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles., PMID:25085576
A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes., PMID:24583283
[Actins and keratins in the diagnosis of human basal-like breast cancer]., PMID:20698309
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9., PMID:20213245
Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a., PMID:19686243
Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice., PMID:19215228
Human sialidase as a cancer marker., PMID:18651674
Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis., PMID:17827720
Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments., PMID:16835219
Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling., PMID:16241905
Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages., PMID:15885103
Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family., PMID:14962670
A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains., PMID:12011038
Expression of Neural Antigens in Normal Xenopus Embryos and Induced Explants: (Xenopus laevis/neural antigens/monoclonal antibodies/neural induction/neural differentiation)., PMID:37280931
For research use only. Not for human or drug use.
