Catalog No.
YHA28501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn295-Gly466
Predicted molecular weight
21.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14744
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRMT5, SKB1 homolog, 72 kDa ICln-binding protein, Jak-binding protein 1, Histone-arginine N-methyltransferase PRMT5, SKB1Hs, JBP1, Shk1 kinase-binding protein 1 homolog, SKB1, HRMT1L5, IBP72, Protein arginine N-methyltransferase 5
Arabidopsis PRMT5 buffers pre-mRNA splicing and development against genetic variation in donor splice sites., PMID:40515451
KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells., PMID:40510131
A proximity-induced chimera platform for targeted protein arginine methylation., PMID:40487645
PRMT5-FOXM1 axis activates β-catenin/IL8 signaling to drive angiogenesis of gastric cancer., PMID:40484103
MicroRNA-100-5p Exacerbates Myocardial Ischemia-Reperfusion Injury Through Downregulation of PRMT5., PMID:40471103
Identification of a Selective Cell-Active Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) for the Treatment of Prostate Cancer by Structure-Based Virtual Screening., PMID:40468526
PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade., PMID:40459496
Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells., PMID:40440106
Drug discovery targeting protein arginine methyltransferase 5 (PRMT5): an update., PMID:40412016
Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy., PMID:40399547
PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C-Myc Feedback Loop., PMID:40384988
MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens., PMID:40377999
Virtual High-Throughput Screening of Ligands for Disrupting PRMT5/pICLn Interaction in Prostate Cancer Cells., PMID:40365403
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma., PMID:40362535
Mechanistic insights into CLNS1A-mediated chemoresistance and tumor progression in non-small cell lung cancer., PMID:40345428
PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti-TIGIT Therapy in Microsatellite-Stable Colorectal Cancer., PMID:40344511
Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal Keratinocyte-Like Cell Population and Defective Epidermal Stratification., PMID:40339790
Caffeic acid borate functionalized linear polyglycidol for targeted siRNA delivery in the treatment of primary biliary cholangitis., PMID:40334881
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias., PMID:40333990
The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells., PMID:40326560
miR-205-3p inhibits porphyromonas gingivalis lipopolysaccharide-induced human umbilical vein endothelial cells inflammation and apoptosis by targeting PRMT5., PMID:40319839
PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites., PMID:40304179
NELFCD Promotes Colon Cancer Progression by Regulating the DUSP2-p38 Axis., PMID:40302325
The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway., PMID:40279519
The expression of PRMT5 is associated with postoperative chemotherapeutic outcome in colon cancer., PMID:40269778
The Histone Methyltransferase PRMT5 Mediates the Epigenetic Modification to Modulate High Temperatures and Tea Quality in Tea Plants (Camellia sinensis)., PMID:40269587
Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease., PMID:40269061
Semaphorin 6A phase separation sustains a histone lactylation-dependent lactate buildup in pathological angiogenesis., PMID:40244673
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader., PMID:40232306
Retraction: Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation., PMID:40219993
Retraction: Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation., PMID:40219992
RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination., PMID:40197797
PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy., PMID:40187753
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms., PMID:40158218
PRMT5 inhibitors: Therapeutic potential in pancreatic cancer., PMID:40157258
Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers., PMID:40146197
Pan-cancer clinical and molecular landscape of MTAP deletion in nationwide and international comprehensive genomic data., PMID:40138743
OsPRMT5 methylates OsPAL1 to promote rice resistance, hindered by a Xanthomonas oryzae effector., PMID:40125805
PRMT5 attenuates regorafenib-induced DNA damage in hepatocellular carcinoma cells through symmetric dimethylation of RPL14., PMID:40115921
From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy., PMID:40102181
High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in high-grade serous ovarian cancer., PMID:40091834
Alternative Splicing Analysis Reveals Adrenergic Signaling as a Novel Target for Protein Arginine Methyltransferase 5 (PRMT5) in the Heart., PMID:40076920
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML., PMID:40057764
PRMT5 highly expressed on CD16 + CD56- natural killer cells is correlated with NK cells exhaustion in colorectal cancer mesenchyme., PMID:40056169
Tumor-intrinsic PRMT5 upregulates FGL1 via methylating TCF12 to inhibit CD8+ T-cell-mediated antitumor immunity in liver cancer., PMID:40041915
Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion., PMID:40035511
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer., PMID:40033101
Quercetin Inhibits Ectopic Lesion Formation in Mice by Modulating the MAT2A/PRMT5 Pathway through PPARγ Activation., PMID:39995138
Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review., PMID:39993609
PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide., PMID:39989968
For research use only. Not for human or drug use.
