Catalog No.
YHK68901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys62-Lys452
Predicted molecular weight
47.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99755
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, PIP5KIalpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, PIP5K1A, Phosphatidylinositol 4-phosphate 5-kinase type I alpha
Renal Dysfunction Induced by Sodium p-Perfluorous Nonenoxybenzenesulfonate in Mice: Insights from the Intrinsic Mechanisms of Proteinuria., PMID:40444664
PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma., PMID:40405713
Dynein-driven regulation of postsynaptic membrane architecture and synaptic function., PMID:39865922
Functional analysis of the PIP5K1A gene in Liaoning Cashmere goats: an investigation based on bioinformatics, tissue localization, and biological functions., PMID:39799498
Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis., PMID:39714186
Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma., PMID:39663392
Silencing CaPIP5K4-1 leads to decreased male fertility in Capsicum annuum L., PMID:39630306
Chiisanoside from the Leaves of Acanthopanax sessiliflorus Can Resist Cisplatin-Induced Ototoxicity by Maintaining Cytoskeletal Homeostasis and Inhibiting Ferroptosis., PMID:39505327
Investigation of the Roles of Phosphatidylinositol 4-Phosphate 5-Kinases 7,9 and Wall-Associated Kinases 1-3 in Responses to Indole-3-Carbinol and Biotic Stress in Arabidopsis Thaliana., PMID:39456186
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer., PMID:39408874
Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback., PMID:39098525
A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells., PMID:39085352
Signal Transduction of Transient Receptor Potential TRPM8 Channels: Role of PIP5K, Gq-Proteins, and c-Jun., PMID:38893478
Pip5k1γ promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII-Ampk pathway in aged mice., PMID:38840443
Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway., PMID:38838507
Identification of cotton PIP5K genes and role of GhPIP5K9a in primary root development., PMID:38705423
1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors., PMID:38669736
Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer., PMID:38565949
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon., PMID:38452758
LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway., PMID:38350542
Circular RNA PIP5K1A Promotes Glucose and Lipid Metabolism Disorders and Inflammation in Type 2 Diabetes Mellitus., PMID:37966664
Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint., PMID:37874883
α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity., PMID:37838947
Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5., PMID:37655623
Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease., PMID:37525039
The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation., PMID:37142675
PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells., PMID:36803256
Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis., PMID:36730637
Fission Yeast PUF Proteins Puf3 and Puf4 Are Novel Regulators of PI4P5K Signaling., PMID:36724944
Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy., PMID:36683155
Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling., PMID:36322759
The role and molecular mechanism of gut microbiota in Graves' orbitopathy., PMID:35986869
Chikungunya virus nsP1 induces migrasome formation., PMID:35933040
The role of PIP5K1A in cancer development and progression., PMID:35852640
β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages., PMID:35841593
Dietary interventions and molecular mechanisms for healthy musculoskeletal aging., PMID:35727468
Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1., PMID:35184688
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling., PMID:35090892
Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha., PMID:35058881
Dishevelled coordinates phosphoinositide kinases PI4KIIIα and PIP5KIγ for efficient PtdInsP2 synthesis., PMID:34982154
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer., PMID:34932854
Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway., PMID:34546850
Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis., PMID:34537072
PIP5KIγ90-generated phosphatidylinositol-4,5-bisphosphate promotes the uptake of Staphylococcus aureus by host cells., PMID:34519119
An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome., PMID:34323415
CircSPAG16 suppresses cadmium-induced transformation of human bronchial epithelial cells by decoying PIP5K1α to inactivate Akt., PMID:34081812
Phospholipase D and phosphatidylinositol-4-phosphate 5-kinase 1 are involved in the regulation of oligodendrocyte morphological differentiation., PMID:34044015
Arabidopsis phosphatidylinositol 4-phosphate 5-kinase genes PIP5K7, PIP5K8, and PIP5K9 are redundantly involved in root growth adaptation to osmotic stress., PMID:33606325
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells., PMID:33591981
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis., PMID:33570734
For research use only. Not for human or drug use.
