Catalog No.
PHC39801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD48 (Gln27-Ser220).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Signaling lymphocytic activation molecule 2,TCT.1,CD48 antigen,B-lymphocyte activation marker BLAST-1,BCM1,CD48,BLAST1,Leukocyte antigen MEM-102,SLAMF2,BCM1 surface antigen,SLAM family member 2
Purification
Purified by antigen affinity column.
Accession
P09326
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. PMID: 17950006
Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48. PMID: 23226623
NMR analysis of interacting soluble forms of the cell-cell recognition molecules CD2 and CD48. PMID: 8634239
Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. PMID: 10556801
Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. PMID: 8627175
Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. PMID: 7520278
Mast cells and eosinophils in allergy: Close friends or just neighbors. PMID: 26526347
Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. PMID: 18079432
SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation. PMID: 20363967
Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site. PMID: 7815555
NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions. PMID: 15210772
Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats. PMID: 26683280
Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway. PMID: 21221603
Expression analysis of two SLAM family receptors, SLAMF2 and SLAMF7, in patients with multiple myeloma. PMID: 31115879
2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. PMID: 9841922
Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. PMID: 12759438
Genomic instability on hMSH2, hMLH1, CD48 and IRF4 loci in pulmonary sarcoidosis. PMID: 12521125
CD59 and CD48 expressed by rat retinal pigment epithelial cells are major ligands for the CD2-mediated alternative pathway of T cell activation. PMID: 8621904
sCD48 is elevated in non-allergic but not in allergic persistent rhinitis. PMID: 34477021
Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression. PMID: 19401429
Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells. PMID: 12496412
Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity. PMID: 18287277
Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48. PMID: 7903240
Decrease in cAMP levels promoted by CD48-CD2 interaction correlates with inhibition of apoptosis in B cells. PMID: 8668920
Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. PMID: 8475091
Prolonged allograft survival by the inhibition of costimulatory CD2 signals but not by modulation of CD48 (CD2 ligand) in the rat. PMID: 8959856
Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48. PMID: 12356317
2B4 inhibits NK-cell fratricide. PMID: 17537992
Alteration of liver immunity by increasing inflammatory response during co-administration of methamphetamine and atazanavir. PMID: 32249638
[Detection of the expression of NK ligands in acute leukemia cell lines by real-time PCR]. PMID: 23597460
Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. PMID: 10823948
Murine epidermal Langerhans cells express CD48, which is a counter-receptor for mouse CD2. PMID: 7487136
Activating interactions in human NK cell recognition: the role of 2B4-CD48. PMID: 10359122
Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48. PMID: 18658158
Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. PMID: 7903681
The chicken SLAM family. PMID: 23064403
Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. PMID: 18626999
Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. PMID: 12734329
Human mast cell activation by Staphylococcus aureus: interleukin-8 and tumor necrosis factor alpha release and the role of Toll-like receptor 2 and CD48 molecules. PMID: 18644875
The murine Cd48 gene: allelic polymorphism in the IgV-like region. PMID: 9949948
Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells. PMID: 30707417
Dormant and self-renewing hematopoietic stem cells and their niches. PMID: 17442778
Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). PMID: 1847502
Analysis of the structure and interactions of CD2. PMID: 7907562
Transcriptional profiling of Foxo3a and Fancd2 regulated genes in mouse hematopoietic stem cells. PMID: 25984447
Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients. PMID: 28386908
Immune Functions of Signaling Lymphocytic Activation Molecule Family Molecules in Multiple Myeloma. PMID: 33451089
CD2 is a dominant target for allogeneic responses. PMID: 12201362
Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. PMID: 32854367
For research use only. Not for human or drug use.
