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Recombinant Human CHMP7 Protein, N-His

Catalog #:   YHK68101 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q8WUX9
Protein length: Leu20-Gly226
Overview

Catalog No.

YHK68101

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Leu20-Gly226

Predicted molecular weight

26.03 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q8WUX9

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Chromatin-modifying protein 7, Charged multivesicular body protein 7, CHMP7

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human CHMP7 Protein
References

Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budding., PMID:39998268

Nuclear ESCRT is involved in intranuclear protein quality control by micronucleophagy., PMID:39721364

CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS., PMID:39709457

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease., PMID:39606446

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes., PMID:39486415

A new microscopy pipeline for studying the initial stages of nuclear and micronuclear rupture and repair., PMID:39359718

Micronuclear collapse from oxidative damage., PMID:39208110

Necroptosis pathway emerged as potential diagnosis markers in spinal cord injury., PMID:38509743

Nuclear pore dysfunction and disease: a complex opportunity., PMID:38383349

Relevance of pyroptosis-associated genes in nasopharyngeal carcinoma diagnosis and subtype classification., PMID:38282154

Highly variable molecular signatures of TDP-43 loss of function are associated with nuclear pore complex injury in a population study of sporadic ALS patient iPSNs., PMID:38168312

Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure., PMID:37795681

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity., PMID:37783794

SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis., PMID:37639327

Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure., PMID:37461528

The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease., PMID:37194062

DNA methylation signature aberration as potential biomarkers in treatment-resistant schizophrenia: Constructing a methylation risk score using a machine learning method., PMID:36442407

Development of a prognostic prediction model based on a combined multi-omics analysis of head and neck squamous cell carcinoma cell pyroptosis-related genes., PMID:36246601

Genomic analysis of the endosomal sorting required for transport complex III pathway genes as therapeutic and prognostic biomarkers for endometrial carcinoma., PMID:36237250

Disruption of nuclear envelope integrity as a possible initiating event in tauopathies., PMID:36001963

Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions., PMID:35962186

Nuclear pore complexes - a doorway to neural injury in neurodegeneration., PMID:35488039

Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis., PMID:35298348

Emerging Connections between Nuclear Pore Complex Homeostasis and ALS., PMID:35163252

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection., PMID:35120190

The ESCRT machinery directs quality control over inner nuclear membrane architecture., PMID:35045304

Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer., PMID:34785938

Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata., PMID:34446013

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS., PMID:34321318

CDK1 controls CHMP7-dependent nuclear envelope reformation., PMID:34286694

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei., PMID:34281622

The pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis., PMID:34215297

Functional validation of CHMP7 as an ADHD risk gene., PMID:33159045

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation., PMID:32601372

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation., PMID:32494070

Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure., PMID:32271860

Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway., PMID:32243490

CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier., PMID:32105978

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system., PMID:30942170

Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy., PMID:30837566

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope., PMID:30513301

Automated analysis of cell migration and nuclear envelope rupture in confined environments., PMID:29649271

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells., PMID:28242692

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation., PMID:27618263

Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis., PMID:27497741

Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7., PMID:26510789

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing., PMID:26040712

Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk., PMID:23028900

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation., PMID:17711858

CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway., PMID:16856878

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human CHMP7 Protein, N-His [YHK68101]
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