Catalog No.
YHK67101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly316-Leu520
Predicted molecular weight
25.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6I4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma., PMID:40197257
Vitamin B12 as a novel USP3 deubiquitinase inhibitor suppresses cell proliferation and growth in osteosarcoma., PMID:40179740
USP3 promotes clear cell renal cell carcinoma progression by stabilizing MYC and enhancing glycolysis., PMID:40164288
The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease., PMID:39996778
Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation., PMID:39837984
The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes., PMID:39702388
USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53., PMID:39694539
Literature review: nuclear factor kappa B (NF-κB) regulation in human cancers mediated by ubiquitin-specific proteases (USPs)., PMID:39507445
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer., PMID:39500888
Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells., PMID:38976206
Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases., PMID:38773075
USP3: Key deubiquitylation enzyme in human diseases., PMID:38651282
USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway., PMID:38531846
USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis., PMID:38502867
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle., PMID:38222562
Bioinformatic Analysis and Experimental Validation of Ubiquitin-Proteasomal System-Related Hub Genes as Novel Biomarkers for Alzheimer's Disease., PMID:38176925
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma., PMID:37980532
USP3 plays a critical role in the induction of innate immune tolerance., PMID:37971847
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin., PMID:37921189
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis., PMID:37348684
CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis., PMID:37170124
Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis., PMID:37013584
Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners., PMID:36574218
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer., PMID:36180571
USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation., PMID:36050480
Exosome-mediated lncRNA SND1-IT1 from gastric cancer cells enhances malignant transformation of gastric mucosa cells via up-regulating SNAIL1., PMID:35739527
A positive feedback loop between LINC01605 and NF-κB pathway promotes tumor growth in nasopharyngeal carcinoma., PMID:35373703
DNA methylation and single-nucleotide polymorphisms in DDX58 are associated with hand, foot and mouth disease caused by enterovirus 71., PMID:35041675
SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein-Protein Interactions., PMID:36883182
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation., PMID:34930901
MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3., PMID:34917199
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3., PMID:34847835
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair., PMID:34811483
Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma., PMID:34758762
USP30-AS1 contributes to mitochondrial quality control in glioblastoma cells., PMID:34653676
A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas., PMID:34536193
Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells., PMID:34070420
An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability., PMID:33767157
A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression., PMID:33346941
LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis., PMID:32918360
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer., PMID:32415280
Limbic System Associated Membrane Protein Mutation in an Iranian Family Diagnosed with Ménière's Disease., PMID:32383616
Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3., PMID:32376451
USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4., PMID:32271432
Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination., PMID:31900278
USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5., PMID:31624151
Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail., PMID:31266817
Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer., PMID:31234902
Universal Solid-Phase Protein Preparation (USP3) for Bottom-up and Top-down Proteomics., PMID:31137935
Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1β induced chondrocyte apoptosis., PMID:31056254
For research use only. Not for human or drug use.
