Catalog No.
YHK63301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp132-Ser328
Predicted molecular weight
24.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBF1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAGEC2, MAGEE1, HCA587, Cancer/testis antigen 10, MAGE-C2 antigen, MAGE-E1 antigen, CT10, Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587
Vaccination with synthetic long peptide and CpG 2395 in AddaVax induces potent anti-tumor effects., PMID:40395227
Immunoinformatic approach to design an efficient multi-epitope peptide vaccine against melanoma., PMID:39245893
An Immunohistochemical Study of MAGE Proteins in Hepatocellular Carcinoma., PMID:39125568
Corrigendum to "MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function" [Biochim. Biophys. Acta, Mol. Cell Res. vol. 1868 (Issue 3) (March 2021) 118918]., PMID:38833988
Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins., PMID:38448672
Application of the iPLUS non-coding sequence in improving biopharmaceuticals production., PMID:38380261
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer., PMID:37341056
Novel diagnostic biomarkers of T cell-mediated tumor killing characteristics for early-stage triple negative breast cancer: A SEER analysis and molecular portraits., PMID:36827041
Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report., PMID:36750254
Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients., PMID:36161330
Clinical Correlation of Function and TCR vβ Diversity of MAGE-C2-Specific CD8+ T Cell Response in Esophageal Cancer., PMID:35970555
The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28., PMID:35927984
Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits., PMID:35743282
Identification of MAGEC2/CT10 as a High Calcium-Inducible Gene in Triple-Negative Breast Cancer., PMID:35355564
Differential gene expression and network analysis in head and neck squamous cell carcinoma., PMID:35142951
Randomized phase II trial of a first-in-human cancer cell lysate vaccine in patients with thoracic malignancies., PMID:34430349
[Expression of melanoma-associated antigen-C2 in breast cancers and mechanism]., PMID:34407585
Increased Melanoma-Associated Antigen C2 Expression Affords Resistance to Apoptotic Deathin Suspension-Cultured Tumor Cells., PMID:33818016
Validation of oral brushing as a non-invasive technique for the identification of feline oral squamous cell carcinoma by DNA methylation and TP53 mutation analysis., PMID:33624422
MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function., PMID:33279609
In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis., PMID:33224314
A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma., PMID:32941982
MAGE-C2/CT10 promotes growth and metastasis through upregulating c-Myc expression in prostate cancer., PMID:32935296
HCA587 Protein Vaccine Induces Specific Antitumor Immunity Mediated by CD4+ T-cells Expressing Granzyme B in a Mouse Model of Melanoma., PMID:32723258
TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma., PMID:32114500
Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer., PMID:31924693
Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer., PMID:31727154
Evaluation of cancer testis antigen (CT10, PRAME) and MHC I expression in high-grade urothelial carcinoma of the bladder., PMID:31485721
Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer., PMID:30736848
Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells., PMID:30309319
Study on Attenuating Angiogenesis and Epithelial-Mesenchymal Transition (EMT) of Non-Small Cell Lung Carcinoma (NSCLC) by Regulating MAGEC2., PMID:30198403
Cancer‑testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells., PMID:29257297
U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma., PMID:29148152
Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas., PMID:28648905
Expression and prognostic relevance of MAGE-A3 and MAGE-C2 in non-small cell lung cancer., PMID:28454298
MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation., PMID:28394358
Correlation between the high expression levels of cancer-germline genes with clinical characteristics in esophageal squamous cell carcinoma., PMID:27868181
Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer., PMID:27843173
The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling., PMID:27775077
Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells., PMID:27636589
MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses., PMID:27489285
Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes., PMID:27165065
[Expression and Clinical Significance of MAGE-C2 in Lung Adenocarcinoma]., PMID:26903162
Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E., PMID:26540345
Cancer-testis antigen MAGEC2 promotes proliferation and resistance to apoptosis in Multiple Myeloma., PMID:26456863
The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance., PMID:26321295
Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma., PMID:26161400
Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma., PMID:26097535
Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area., PMID:26057582
Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers., PMID:25576290
For research use only. Not for human or drug use.
