Catalog No.
YHD93101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser313
Predicted molecular weight
37.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31152
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP kinase 4, Extracellular signal-regulated kinase 4, ERK4, MAPK 4, Mitogen-activated protein kinase 4, MAPK4, ERK-4, PRKM4, MAP kinase isoform p63, p63-MAPK
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis., PMID:40308884
A Spermidine Derivative Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Inhibiting the MAPK4/AKT Signaling Pathway., PMID:40238233
A VqMAPK4-VqGT3-VqNSTS6 module regulates powdery mildew resistance via stilbene biosynthesis in Chinese wild grapevine., PMID:40203126
p53 transcriptionally activates DCP1B to suppress tumor progression and enhance tumor sensitivity to PI3K blockade in non-small cell lung cancer., PMID:40200093
MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway., PMID:39863600
Microcystin-LR Exposure Damages Neurons by Inducing α-Syn Aggregation via MAPK4/GATA2/SNCA and PP2A/GRKs Pathways., PMID:39738876
C6 and KLRG2 are pyroptosis subtype-related prognostic biomarkers and correlated with tumor-infiltrating lymphocytes in lung adenocarcinoma., PMID:39438534
Anti-liver cancer therapeutic targets and safety of usenamine A in experimental liver cancer., PMID:39360781
Atypical MAPKs in cancer., PMID:39348153
Puerarin Decreases the Expression of FUS-Dependent MAPK4 to Inhibit the Development of Triple-Negative Breast Cancer., PMID:39223105
Interleukin-1β-stimulated macrophage-derived exosomes improve myocardial injury in sepsis via regulation of mitochondrial homeostasis: experimental research., PMID:38967516
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer., PMID:38947754
A review of non-classical MAPK family member, MAPK4: A pivotal player in cancer development and therapeutic intervention., PMID:38801852
[Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning]., PMID:38785053
Leishmania major MAPK4 intercepts and redirects CD40 signaling promoting infection., PMID:38728877
Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma., PMID:38685086
[Deciphering cellular processes responding to lethality of 17β-estradiol by quantitative phosphoproteomics]., PMID:38566422
Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus., PMID:38494098
LINC00467 enhanced the proliferative, migratory and invasive ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis., PMID:38279470
Molecular Targets and Mechanisms of Casein-Derived Tripeptides Ile-Pro-Pro and Val-Pro-Pro on Hepatic Glucose Metabolism., PMID:38011324
scTIGER: A Deep-Learning Method for Inferring Gene Regulatory Networks from Case versus Control scRNA-seq Datasets., PMID:37686146
A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis., PMID:37550229
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy., PMID:37531320
Genetic Polymorphisms of rs9949644 in MAPK4 Are Associated with Clinical Response to Methotrexate in Patients with Psoriasis., PMID:37494889
Deoxythymidylate kinase (DTYMK) participates in cell cycle arrest to promote pancreatic adenocarcinoma progression regulated by miR-491-5p through TP53 and is associated with tumor immune infiltration., PMID:37435228
MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway., PMID:36999945
Comprehensive analysis of the PTPN13 expression and its clinical implication in breast cancer., PMID:36812232
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages., PMID:36797541
The role of atypical MAP kinase 4 in the host interaction with Cryptosporidium parvum., PMID:36658270
miR-576-5p Promotes the Proliferation of Papillary Thyroid Carcinoma through the MAPK4-AKT Pathway., PMID:36618768
An integrated physiology, cytology, and proteomics analysis reveals a network of sugarcane protoplast responses to enzymolysis., PMID:36518493
RNA-Seq exploration of the influence of stress on meat quality in Spanish goats., PMID:36446782
The roles and mechanisms of circular RNAs related to mTOR in cancers., PMID:36426933
Promotor methylation status of MAPK4 is a novel epigenetic biomarker for prognosis of recurrence in patients with thymic epithelial tumors., PMID:36073321
Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF-κb signaling pathway., PMID:36045396
The silencing of miR-199a-5p protects the articular cartilage through MAPK4 in osteoarthritis., PMID:35722355
Modulation of Host Immune Response during Leishmania infantum Natural Infection: A Whole-Transcriptome Analysis of the Popliteal Lymph Nodes in Dogs., PMID:35058931
Mitogen-Activated Protein Kinase 4-Regulated Metabolic Networks., PMID:35055063
MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade., PMID:35017531
Identification of Potential Osteoporosis miRNA Biomarkers Using Bioinformatics Approaches., PMID:34777562
MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells., PMID:34080025
MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT., PMID:33586682
Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways., PMID:33398248
MiR-127-3p inhibits proliferation of ovarian cancer in rats through down-regulating MAPK4., PMID:33155194
C/EBPα/miR-7 Controls CD4+ T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice., PMID:33125780
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury., PMID:33088477
Tea Tree Oil Prevents Mastitis-Associated Inflammation in Lipopolysaccharide-Stimulated Bovine Mammary Epithelial Cells., PMID:32851050
Comparison the effects of hypoxia-mimicking agents on migration-related signaling pathways in mesenchymal stem cells., PMID:32815062
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer., PMID:32711558
MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy., PMID:32443670
For research use only. Not for human or drug use.
