Catalog No.
YHF64301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu225
Predicted molecular weight
27.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78330
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
O-phosphoserine phosphohydrolase, Phosphoserine phosphatase, L-3-phosphoserine phosphatase, PSP, PSPH, PSPase
PSPH promotes the proliferation and metastasis of esophageal squamous cell carcinoma through MAPK signaling pathways., PMID:40371136
Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae., PMID:40162990
FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction., PMID:39773485
N6-Methyladenosine modification activates the serine synthesis pathway to mediate therapeutic resistance in liver cancer., PMID:39489921
Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021., PMID:39304265
Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells., PMID:39059599
The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism., PMID:38825643
L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase., PMID:38816452
Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review., PMID:38742477
Composite alginate-based hydrogel delivery of antioxidant pumpkin protein hydrolysate in simulated gastrointestinal condition., PMID:38708103
Multi-layer encapsulation of pumpkin (Cucurbita maxima L.) seed protein hydrolysate and investigating its release and antioxidant activity in simulated gastrointestinal digestion., PMID:38681570
Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells., PMID:38656254
Deciphering the Impact of Rare Missense Variants in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer through Whole Exome Sequencing: A Computational Approach., PMID:38617633
Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice., PMID:38573412
Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial., PMID:38483735
AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth., PMID:38098117
A Comprehensive Bioinformatics Resource Guide for Genome-Based Antimicrobial Resistance Studies., PMID:37861712
Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner., PMID:37823569
Constructing and interpreting a large-scale variant effect map for an ultrarare disease gene: Comprehensive prediction of the functional impact of PSAT1 genotypes., PMID:37812589
The Dipeptide Gly-Pro (GP), Derived from Hibiscus sabdariffa, Exhibits Potent Antifibrotic Effects by Regulating the TGF-β1-ATF4-Serine/Glycine Biosynthesis Pathway., PMID:37686422
Integrated of multi-omics and molecular docking reveal PHGDH, PSAT1 and PSPH in the serine synthetic pathway as potential targets of T-2 toxin exposure in pig intestinal tract., PMID:37678681
Increased serine synthesis in cumulus cells of young infertile women with diminished ovarian reserve., PMID:37533289
Influence of the concentrate inclusion level in a grass silage-based diet on hepatic transcriptomic profiles in Holstein-Friesian dairy cows in early lactation., PMID:37474362
Novel genes associated with a placental phenotype in knockout mice also respond to cellular stressors in primary human trophoblasts., PMID:37331027
Study on the Mechanism of MC5R Participating in Energy Metabolism of Goose Liver., PMID:37239994
Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy., PMID:36849198
Predicting the functional effect of compound heterozygous genotypes from large scale variant effect maps., PMID:36711904
Multi-omics Analysis of the Role of PHGDH in Colon Cancer., PMID:36707056
ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH., PMID:36639869
Probing Folate-Responsive and Stage-Sensitive Metabolomics and Transcriptional Co-Expression Network Markers to Predict Prognosis of Non-Small Cell Lung Cancer Patients., PMID:36615660
Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys., PMID:35625086
β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses., PMID:35603790
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells., PMID:35594343
Identification of zinc-chelating pumpkin seed (Cucurbita pepo L.) peptides and in vitro transport of peptide-zinc chelates., PMID:35340027
The Integration of Metabolomic and Proteomic Analyses Revealed Alterations in Inflammatory-Related Protein Metabolites in Endothelial Progenitor Cells Subjected to Oscillatory Shear Stress., PMID:35250628
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway., PMID:35186770
ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction., PMID:34551291
Optimized protocols for ChIP-seq and deletion mutant construction in Pseudomonas syringae., PMID:34485942
Regulation of Gene Expression by Amino Acids in Animal Cells., PMID:34251635
Targeting Serine in Cancer: Is Two Better Than One?, PMID:34219053
RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen., PMID:33932994
Effect of Enzymatic Hydrolysis on the Zinc Binding Capacity and in vitro Gastrointestinal Stability of Peptides Derived From Pumpkin (Cucurbita pepo L.) Seeds., PMID:33869265
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1., PMID:33674745
Plantaginis Semen polysaccharides ameliorate renal damage through regulating NLRP3 inflammasome in gouty nephropathy rats., PMID:33624653
Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism., PMID:33444686
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism., PMID:33361394
Transcriptome assisted label free proteomics of hepatic tissue in response to both dietary restriction and compensatory growth in cattle., PMID:33217582
Immunostimulatory Effects of Polysaccharides from Spirulina platensis In Vivo and Vitro and Their Activation Mechanism on RAW246.7 Macrophages., PMID:33126624
PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway., PMID:33079432
Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression., PMID:33051595