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Recombinant Human HADHA Protein, N-His

Catalog #:   YHE28601 Specific References (49) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P40939
Protein length: Gly31-Gln763
Overview

Catalog No.

YHE28601

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Gly31-Gln763

Predicted molecular weight

81.83 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P40939

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

78 kDa gastrin-binding protein, HADH, HADHA, Trifunctional enzyme subunit alpha, mitochondrial, TP-alpha, Monolysocardiolipin acyltransferase

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human HADHA Protein
References

Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation., PMID:40425566

In-silico discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs., PMID:40370100

SENP3 induced HADHA deSUMOylation enhances intrahepatic cholangiocarcinoma chemotherapy sensitivity via fatty acid oxidation., PMID:40320039

Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species., PMID:40164334

Bioinformatics-Guided Identification and Quantification of Biomarkers of Crotalus atrox Envenoming and Its Neutralization by Antivenom., PMID:40147718

The Role of HADHB in Mitochondrial Fatty Acid Metabolism During Initiation of Metastasis in ccRCC., PMID:39991877

Sudden Death of a Four-Day-Old Newborn Due to Mitochondrial Trifunctional Protein/Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiencies and a Systematic Literature Review of Early Deaths of Neonates with Fatty Acid Oxidation Disorders., PMID:39982343

Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction., PMID:39870300

Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing., PMID:39723123

Peripheral Neuropathy in Mitochondrial Trifunctional Protein Deficiency due to a Variant in HADHA Gene., PMID:39687448

Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profiles., PMID:39623870

Phenotypic and Genetic Spectrum in 309 Consecutive Pediatric Patients with Inherited Retinal Disease., PMID:39596324

GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease., PMID:39505148

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS., PMID:39488787

Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice., PMID:39438446

Periodic Paralysis in a Child With Thermosensitive Mitochondrial Trifunctional Protein Deficiency., PMID:39360520

HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis., PMID:39327932

TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis., PMID:39325960

iPSC-Derived LCHADD Retinal Pigment Epithelial Cells Are Susceptible to Lipid Peroxidation and Rescued by Transfection of a Wildtype AAV-HADHA Vector., PMID:39283617

Lactucopicrin promotes fatty acid β-oxidation and attenuates lipid accumulation through adenosine monophosphate-activated protein kinase activation in free fatty acid-induced human hepatoblastoma cancer cells., PMID:39139977

Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency., PMID:39088276

HADHA promotes glioma progression by accelerating MDM2-mediated p53 ubiquitination., PMID:39039194

Effects of different energy levels in low-protein diet on liver lipid metabolism in the late-phase laying hens through the gut-liver axis., PMID:38987834

Arsenic exposure at environmentally relevant levels induced metabolic toxicity in development mice: Mechanistic insights from integrated transcriptome and metabolome., PMID:38906090

Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators., PMID:38848460

Compartmental Differences in the Retinal Ganglion Cell Mitochondrial Proteome., PMID:38766051

Integrative analysis of proteomics and lipidomic profiles reveal the fat deposition and meat quality in Duroc × Guangdong small spotted pig., PMID:38659450

TFP/LCHAD Deficiency Due to HADHA Gene Mutation., PMID:38379183

Protein lysine acetylation played an important role in NH3-induced AEC2 damage and pulmonary fibrosis in piglets., PMID:37939958

The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis., PMID:37893980

Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation., PMID:37843279

New Acylcarnitine Ratio as a Reliable Indicator of Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency., PMID:37754774

A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency., PMID:37644104

Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa., PMID:37625146

F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit., PMID:37576703

An Autopsy Analysis of a Patient With Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Caused by Compound Heterozygous HADHA Gene Mutations., PMID:37549033

IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption., PMID:37544897

Development of tryptophan metabolism patterns to predict prognosis and immunotherapeutic responses in hepatocellular carcinoma., PMID:37540213

A Comprehensive LOVD Database for Fatty Acid Oxidation Disorders in Chinese Populations., PMID:40225143

Proteomics analyses of acute kidney injury biomarkers in a rat exertional heat stroke model., PMID:37378075

ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock., PMID:36992838

Dietary T-2 toxin induces transcriptomic changes in hepatopancreas of Chinese mitten crab (Eriocheir sinensis) via nutrition metabolism and apoptosis-related pathways., PMID:36527851

HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathway., PMID:36376538

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination., PMID:36273042

Abnormal expression of HADH, an enzyme of fatty acid oxidation, affects tumor development and prognosis (Review)., PMID:36239258

[HADHA Inhibits the Migration and Invasion of HTR-8/SVneo Cells by Regulating PI3K/AKT Signaling Pathway]., PMID:36224682

Outcomes of mitochondrial long chain fatty acid oxidation and carnitine defects from a single center metabolic genetics clinic., PMID:36109795

Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension., PMID:36093169

Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism., PMID:36055749

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human HADHA Protein, N-His [YHE28601]
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