Catalog No.
YHF88601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala192
Predicted molecular weight
24.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01664
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activating enhancer-binding protein 4, bHLHc41, Class C basic helix-loop-helix protein 41, BHLHC41, TFAP4, Transcription factor AP-4
Genetic Associations of ACOX2 Gene with Milk Yield and Composition Traits in Chinese Holstein Cows., PMID:40218347
The development of pyridazinone-based andrographolide derivatives as anti-cancer agents with the ability of inhibiting the TFAP4/Wnt/β-catenin signaling pathway., PMID:40215943
Genome-wide CRISPR screen identifies IRF1 and TFAP4 as transcriptional regulators of Galectin-9 in T cell acute lymphoblastic leukemia., PMID:40106574
TFAP4 Regulation of MCM5 Activates the PI3K/AKT Pathway to Promote Invasion and Metastasis of Gastric Cancer., PMID:39971831
In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells., PMID:39839902
TFAP4 regulates the progression of liver fibrosis through the STING signaling pathway., PMID:39827671
circ_0006988 promotes gastric cancer cell proliferation, migration and invasion through miRNA-92a-2-5p/TFAP4 axis., PMID:39400106
USP15, activated by TFAP4 transcriptionally, stabilizes SHC1 via deubiquitination and deteriorates renal cell carcinoma., PMID:38847328
Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness., PMID:38801926
Predictive value of immediate early response 5 like (IER5L) in the prognosis and immune checkpoint blockade therapy of non-small cell lung cancer patients., PMID:38552564
Chromatin profiling reveals TFAP4 as a critical transcriptional regulator of bovine satellite cell differentiation., PMID:38475725
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation., PMID:37995683
Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression., PMID:37705742
Downregulation of miR-144 blocked the proliferation and invasion of nerve cells in Hirschsprung disease by regulating Transcription Factor AP 4 (TFAP4)., PMID:37610449
TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40., PMID:37060810
Targeting NK-1R attenuates renal fibrosis via modulating inflammatory responses and cell fate in chronic kidney disease., PMID:37033943
Conserved Molecular Players Involved in Human Nose Morphogenesis Underlie Evolution of the Exaggerated Snout Phenotype in Cichlids., PMID:36930462
Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis., PMID:36894688
Identification of a novel senescence-associated signature to predict biochemical recurrence and immune microenvironment for prostate cancer., PMID:36891298
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer., PMID:36548402
Global and precise identification of functional miRNA targets in mESCs by integrative analysis., PMID:35899551
AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p., PMID:35624466
Cucurbitacin E Triggers Cellular Senescence in Colon Cancer Cells via Regulating the miR-371b-5p/TFAP4 Signaling Pathway., PMID:35192356
Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma., PMID:35001801
Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis., PMID:34992355
Upregulating microRNA-373-3p promotes apoptosis and inhibits metastasis of hepatocellular carcinoma cells., PMID:34983307
TFAP4 promotes the growth of prostate cancer cells by upregulating FOXK1., PMID:34630654
A novel variant in DYNC1H1 could contribute to human amyotrophic lateral sclerosis-frontotemporal dementia spectrum., PMID:34535505
Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes., PMID:34283887
Silencing of the Long Non-Coding RNA TTN-AS1 Attenuates the Malignant Progression of Osteosarcoma Cells by Regulating the miR-16-1-3p/TFAP4 Axis., PMID:34141611
Corrigendum: MicroRNA-608 Promotes Apoptosis in Non-Small Cell Lung Cancer Cells Treated With Doxorubicin Through the Inhibition of TFAP4., PMID:33859675
MicroRNA-124 suppresses the invasion and proliferation of breast cancer cells by targeting TFAP4., PMID:33717268
Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die., PMID:33567514
Expression of MiR-608 in Nonsmall Cell Lung Cancer and Molecular Mechanism of Apoptosis and Migration of A549 Cells., PMID:33426072
An integrated pan-cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity., PMID:33373169
HLH-11 modulates lipid metabolism in response to nutrient availability., PMID:33235199
Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling., PMID:33205649
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes., PMID:33034061
Screening of potential genes and transcription factors involved in post-radiation cognitive dysfunction in mice via bioinformatics., PMID:35117246
Transcription factor AP-4 (TFAP4)-upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA-520f-3p feedback loop., PMID:31943575
MicroRNA-608 Promotes Apoptosis in Non-Small Cell Lung Cancer Cells Treated With Doxorubicin Through the Inhibition of TFAP4., PMID:31552102
The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression., PMID:31530880
TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway., PMID:31281549
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes., PMID:31036568
Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells., PMID:30177706
Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma., PMID:30026867
MicroRNA-302c represses epithelial-mesenchymal transition and metastasis by targeting transcription factor AP-4 in colorectal cancer., PMID:29906744
Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma., PMID:29880876
Elevated TFAP4 regulates lncRNA TRERNA1 to promote cell migration and invasion in gastric cancer., PMID:29845218
Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients., PMID:28912857