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Research Grade Anti-Ganglioside GD2 (ATL301)

Catalog #:   DHK07801 Specific References (49) DATASHEET
Host species: Human
Isotype: IgG
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHK07801

Expression system

Mammalian Cells

Species reactivity

General

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Target

Ganglioside GD2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 65988-71-8

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

ATL301

Clone ID

ATL301

Data Image
References

Combining CD3/GD2 bispecific T cell engager with human Vγ9Vδ2 T cells facilitates neuroblastoma cell targeting and killing in vitro., PMID:40489497

Endocytosis Properties of GD2-Specific Antibodies in Tumor Cells., PMID:40367084

Ocular Toxicity in GD-2 Antibody Therapy: A Case Study., PMID:40247734

The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial., PMID:39952926

GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics., PMID:39921214

Antibody-Dependent Cellular Cytotoxicity of iPS Cell-Derived Natural Killer T Cells by Anti-GD2 mAb for Neuroblastoma., PMID:39916425

GD2-targeted theranostics of neuroblastoma with [64Cu]Cu/[177Lu]Lu-hu3F8., PMID:39702399

Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins., PMID:39684463

Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma., PMID:39668192

Prospects of anti-GD2 immunotherapy for retinoblastoma., PMID:39620227

Tuning the Protonation Sensitivity of Weak Acidic Groups on a Zwitterionic Dendrimer for Selectively Targeting GD2-Overexpressed Tumor Cells in an Acidic Tumor Microenvironment., PMID:39481027

Immunoliposomes for Neuroblastoma: Review of the Past Experience and Design of a Novel Nanoparticle., PMID:39477321

GD2 in Breast Cancer: A Potential Biomarker and Therapeutic Target., PMID:39467630

Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma., PMID:39407274

Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediates potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells., PMID:39395135

Niraparib Enhances and Synergizes with Ganglioside GD2 to Potentiate its Inhibitory Effect on Bladder Cancer Cells., PMID:39354757

High-Risk Neuroblastoma Challenges and Opportunities for Antibody-Based Cellular Immunotherapy., PMID:39200906

Omalizumab for Treatment of Anti-GD2 Antibody-related Urticaria., PMID:39177945

Protocol for assessing GD2 on formalin-fixed paraffin-embedded tissue sections using immunofluorescence staining., PMID:39046881

Long Prime-Boost Interval and Heightened Anti-GD2 Antibody Response to Carbohydrate Cancer Vaccine., PMID:38932316

Enhanced anti-tumor activity mediated by combination chimeric antigen receptor T cells targeting GD2 and GPC2 in high-risk neuroblastoma., PMID:38904586

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior., PMID:38866755

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells., PMID:38736882

Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells., PMID:38495105

Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment-Drug Conjugates Carrying Maytansinoids DM1 and DM4., PMID:37886955

Biology of GD2 ganglioside: implications for cancer immunotherapy., PMID:37670947

Effect and Tolerance of N5 and N6 Chemotherapy Cycles in Combination with Dinutuximab Beta in Relapsed High-Risk Neuroblastoma Patients Who Failed at Least One Second-Line Therapy., PMID:37444475

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior., PMID:36993422

Minibody-Based and scFv-Based Antibody Fragment-Drug Conjugates Selectively Eliminate GD2-Positive Tumor Cells., PMID:36674755

Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial., PMID:36547975

Immune Response and Outcome of High-Risk Neuroblastoma Patients Immunized with Anti-Idiotypic Antibody Ganglidiomab: Results from Compassionate-Use Treatments., PMID:36497290

Apoptosis is responsible for the cytotoxic effects of anti-GD2 ganglioside antibodies and aurora A kinase inhibitors on human neuroblastoma cells., PMID:35810485

Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors., PMID:35764367

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies., PMID:35086947

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins., PMID:35008849

Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome the Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development., PMID:34469031

Immunomonitoring of Stage IV Relapsed Neuroblastoma Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation and Subsequent GD2 (ch14.18/CHO) Antibody Treatment., PMID:34367149

Using a combination of gangliosides and cell surface vimentin as surface biomarkers for isolating osteosarcoma cells in microfluidic devices., PMID:33912384

Depth of tumor implantation affects response to in situ vaccination in a syngeneic murine melanoma model., PMID:33858849

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells., PMID:33722905

Exploiting Gangliosides for the Therapy of Ewing's Sarcoma and H3K27M-Mutant Diffuse Midline Glioma., PMID:33572900

Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression., PMID:33326254

GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma., PMID:33303017

The glycosphingolipid GD2 as an effective but enigmatic target of passive immunotherapy in children with aggressive neuroblastoma (HR-NBL)., PMID:33271265

Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death., PMID:33252182

Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer., PMID:33015525

A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy., PMID:32958698

Gangliosides and Neuroblastomas., PMID:32726962

Recent advances in tumor associated carbohydrate antigen based chimeric antigen receptor T cells and bispecific antibodies for anti-cancer immunotherapy., PMID:31982247

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Anti-Ganglioside GD2 (ATL301) [DHK07801]
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