Anti-Human HMGB1 Antibody (SAA0503)

Catalog No.

RHC40301

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P09429

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA0503

Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway., PMID:40504080

HMGB1 mediates inflammation response of epileptogenicity in tuberous sclerosis complex-related epilepsy., PMID:40501216

Patritumab deruxtecan induces immunogenic cell death., PMID:40458967

Evaluation of Tissue Expression of HMBG1 protein in Patients With Breast Cancer., PMID:40437918

Biliary atresia: Rotavirus amplification of lipopolysaccharide/toll-like receptor 4 by mediating MMP7 upregulation through NF-κB., PMID:40415071

Anti-DAMP therapies for acute inflammation., PMID:40406124

Sterile Inflammation and Cell Death Pathways in Liver Ischemia-Reperfusion Injury: A Review and Perspective., PMID:40396312

A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer., PMID:40394677

Intradermal Injection of a Protein Alone Without Additional Adjuvants Using a Needle-Free Pyro-Drive Jet Injector Induces Potent CD8+ T Cell-Mediated Antitumor Immunity., PMID:40362678

HMGB1 Regulates Adipocyte Lipolysis via Caveolin-1 Signaling: Implications for Metabolic and Cardiovascular Diseases., PMID:40362460

Anti-Oxidized Low-Density Lipoprotein Antibodies Before and After Intravenous Immunoglobulin Therapy in Kawasaki Disease　- Evidence for a Potentially Protective Role., PMID:40352122

The anti-FRα antibody-drug conjugate luveltamab tazevibulin demonstrates efficacy in non-small cell lung cancer preclinical models and induces immunogenic cell death., PMID:40293943

HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice., PMID:40274181

Surface-Modified Micro-Ring-Resonator Sensors for HMGB1 Detection on a Chip-Scale Platform., PMID:40223648

Unveiling the Therapeutic Potential of Dulaglutide in Mitigating Tacrolimus-Induced Nephrotoxicity Through Targeting the miR-22/HMGB-1/TLR4/MyD88/NF-κB Trajectory., PMID:40205909

Hepatic Stellate Cells Activated by Cancer Cell-derived AMIGO2-containing Small Extracellular Vesicles Promote Cancer Cell Migration by Producing IL-8., PMID:40155010

Inhibiting the Translocation of HMGB1 Alleviates Renal Ischemia-Reperfusion Injury by Cutting Down Inflammatory Cascade., PMID:40107932

Highlights from the breakout session: vasculitis in paediatric rheumatology., PMID:40071400

An engineered peptide derived from the innate immune effector high-mobility group box 1 disrupts and prevents dual-genera biofilms formed by common respiratory tract pathogens., PMID:40036662

HMGB1 drives T-cell activation in hypertensive males and females., PMID:39982439

Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers., PMID:39981242

Oxidative High Mobility Group Box-1 Accelerates Mitochondrial Transfer from Mesenchymal Stem Cells to Colorectal Cancer Cells Providing Cancer Cell Stemness., PMID:39940960

HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC., PMID:39853458

High mobility group box1 as a danger signal inducing the infiltration of neutrophils and macrophages in thioacetamide-induced rat liver injury., PMID:39839722

A novel bioassay reflecting response to immune checkpoint inhibitor therapy in non-small cell lung cancer with malignant pleural effusion., PMID:39830737

HMGB1 induces unexplained recurrent spontaneous abortion by mediating decidual macrophage autophagy., PMID:39787761

Ionizable polymeric micelles (IPMs) for efficient siRNA delivery., PMID:39753560

TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer., PMID:39722406

Roles of macrophages in lupus nephritis., PMID:39611168

High circulating HMGB1 indicates good prognosis in patients with advanced leiomyosarcoma under chemoimmunotherapy., PMID:39572927

Echinochrome A inhibits HMGB1-induced vascular smooth muscle cell migration by suppressing osteopontin expression., PMID:39539178

Chemokine CXCL13 facilitates anti-FVIII inhibitory antibody development in hemophilia A patients and murine models., PMID:39471695

Epigallocatechin-3-gallate induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer., PMID:39471680

CXCL13/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia., PMID:39454362

Neoantigen sequestrated autophagosomes as therapeutic cancer vaccines., PMID:39413847

Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer., PMID:39373859

Euphorbia Pekinensis Rupr. sensitizes colorectal cancer to PD-1 blockade by remodeling the tumor microenvironment and enhancing peripheral immunity., PMID:39368338

Phase Ib Study for the Combination of Doxorubicin, Dacarbazine, and Nivolumab as the Upfront Treatment in Patients With Advanced Leiomyosarcoma: A Study by the Spanish Sarcoma Group (GEIS)., PMID:39356980

High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-κB pathway following spinal cord injury., PMID:39333662

Roles of HMGB1 on life-threatening traumatic brain injury and sequential peripheral organ damage., PMID:39271757

Noninflammatory 97-amino acid High Mobility Group Box 1 derived polypeptide disrupts and prevents diverse biofilms., PMID:39182358

Immune responses in COVID-19 patients: Insights into cytokine storms and adaptive immunity kinetics., PMID:39149061

Serum HMGB-1 released by ferroptosis and necroptosis as a novel potential biomarker for systemic lupus erythematosus., PMID:39128419

Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia., PMID:39121610

Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT)., PMID:39119813

HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke., PMID:39117343

Natural triterpenoid-aided identification of the druggable interface of HMGB1 occupied by TLR4., PMID:39092445

Soluble E-Cadherin Contributes to Airway Inflammation in Severe Asthma., PMID:39079117

Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages., PMID:39029270

Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage., PMID:39000167

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Anti-Human HMGB1 Antibody (SAA0503).pdf