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InVivoMAb Anti-HIV1 gp120/Glycoprotein 120 (Iv0038) (VVV03102)

Host species:Human
Isotype:IgG1, lambda2
Applications:ELISA, Neutralization
Accession:Q03805
Overview

Catalog No.

VVV03102

Species reactivity

Human immunodeficiency virus 1 (HIV-1)

Host species

Human

Isotype

IgG1, lambda2

Clonality

Monoclonal

Target

Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 41, gp41, env

Concentration

2.2 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q03805

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0038

Data Image
  • SDS-PAGE
    SDS PAGE for HIV1 gp120/Glycoprotein 120 (Iv0038)
References

Hidden dUTPase sequence in human immunodeficiency virus type 1 gp120. PMID: 9847382

HIV-1 gp120 and immune network. PMID: 15370273

The alpha helix 1 from the first conserved region of HIV1 gp120 is reconstructed in the short NQ21 peptide. PMID: 29273432

The HIV-1 gp120 V1V2 loop: structure, function and importance for vaccine development. PMID: 25163695

Entry inhibitors directed towards glycoprotein gp120: an overview on a promising target for HIV-1 therapy. PMID: 23278399

The SPL7013 dendrimer destabilizes the HIV-1 gp120-CD4 complex. PMID: 26495445

HIV gp120: double lock strategy foils host defences. PMID: 9739096

Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance. PMID: 20129670

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate. PMID: 25915761

Plugging gp120s cavity. PMID: 19000812

Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity. PMID: 23297802

Viral surface glycoproteins, gp120 and gp41, as potential drug targets against HIV-1: brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug. PMID: 21345545

Computational design, synthesis and evaluation of new sulphonamide derivatives targeting HIV-1 gp120. PMID: 31792886

NMR observation of HIV-1 gp120 conformational flexibility resulting from V3 truncation. PMID: 24819826

A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization. PMID: 20527993

Variability in the Glycosylation Patterns of gp120 Proteins from Different Human Immunodeficiency Virus Type 1 Isolates Expressed in Different Host Cells. PMID: 34448591

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. PMID: 29051495

gp120: Biologic aspects of structural features. PMID: 11244037

Genetic variability of HIV-1. PMID: 8883605

[Structural mechanism of immune evasion of HIV-1 gp120 by genomic, computational, and experimental science]. PMID: 21972555

Allosteric induction of the CD4-bound conformation of HIV-1 Gp120. PMID: 24304511

Structure and Dynamics of the Native HIV-1 Env Trimer. PMID: 25762739

Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41. PMID: 12769725

The gp120 protein is a second determinant of decreased neurovirulence of Indian HIV-1C isolates compared to southern African HIV-1C isolates. PMID: 25188269

A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4. PMID: 28429756

The HIV-1 gp120 major variable regions modulate cold inactivation. PMID: 23345516

Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells. PMID: 20471426

The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry. PMID: 23916815

Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. PMID: 24502450

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. PMID: 11188697

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility. PMID: 20080564

Stoichiometric parameters of HIV-1 entry. PMID: 25463598

Insight derived from molecular dynamics simulations into molecular motions, thermodynamics and kinetics of HIV-1 gp120. PMID: 25105502

[Structure and function of oligosaccharide chains of the envelope glycoprotein gp120 of human immunodeficiency virus type 1]. PMID: 1518160

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel. PMID: 26018158

Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments. PMID: 22117536

Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange. PMID: 20660185

Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564. PMID: 15207637

Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. PMID: 2187500

Correlated mutations at gp120 positions 322 and 440: implications for gp120 structure. PMID: 18275085

Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions. PMID: 7678271

Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site. PMID: 12502824

Global N-Glycan Site Occupancy of HIV-1 gp120 by Metabolic Engineering and High-Resolution Intact Mass Spectrometry. PMID: 27984693

Prediction of the secondary structure of HIV-1 gp120. PMID: 8727315

HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview. PMID: 25517345

Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. PMID: 20638388

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay. PMID: 24158809

HIV-1 entry inhibitors in the side pocket. PMID: 10555140

[Sequence variation of HIV and bioinformatics]. PMID: 15449902

Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor. PMID: 34372601

Characterization of the outer domain of the gp120 glycoprotein from human immunodeficiency virus type 1. PMID: 15542649

The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site. PMID: 18378683

Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity. PMID: 28446609

Inhibition of HIV entry by carbohydrate-binding proteins. PMID: 16569440

Binding of HIV-1 gp120 to the nicotinic receptor. PMID: 1397297

gp120 sequences from HIV type 1 subtype C early seroconverters in India. PMID: 15320993

Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120. PMID: 10196334

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120. PMID: 29463753

Molecular docking guided structure based design of symmetrical N,N'-disubstituted urea/thiourea as HIV-1 gp120-CD4 binding inhibitors. PMID: 23777826

Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies. PMID: 22906742

Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection. PMID: 24657436

Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity. PMID: 20357769

Sequence-conserved and antibody-accessible sites in the V1V2 domain of HIV-1 gp120 envelope protein. PMID: 25051095

Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors. PMID: 19410340

Characterization of human immunodeficiency virus type 1 gp120 binding to liposomes containing galactosylceramide. PMID: 8057468

Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction. PMID: 22192629

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention. PMID: 18930512

Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding. PMID: 8416385

The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions. PMID: 23255784

The role of the viral glycoprotein in HIV-1 persistence. PMID: 10065629

Antibody neutralization of human immunodeficiency virus type 1 (HIV-1). PMID: 12739253

Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion. PMID: 21647388

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition. PMID: 12954207

Ethnic differences in the adaptation rate of HIV gp120 from a vaccine trial. PMID: 19604405

Combinatorial libraries, epitope structure and the prediction of protein conformations. PMID: 9078681

A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption. PMID: 23470147

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions. PMID: 34517280

HIV gp120 V(1)/V(2) and C(2)-V(3) domains glycoprotein compatibility is required for viral replication. PMID: 11551649

Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340. PMID: 23815775

HIV-1 virion-cell interactions: an electrostatic model of pathogenicity and syncytium formation. PMID: 8018384

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. PMID: 28348411

Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides. PMID: 12565922

Specific VpU codon changes were significantly associated with gp120 V3 tropic signatures in HIV-1 B-subtype. PMID: 23271577

The highly conserved glycan at asparagine 260 of HIV-1 gp120 is indispensable for viral entry. PMID: 22006924

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint. PMID: 34469718

The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures. PMID: 8806809

CCR5 structural plasticity shapes HIV-1 phenotypic properties. PMID: 30521629

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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InVivoMAb Anti-HIV1 gp120/Glycoprotein 120 (Iv0038) [VVV03102]
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