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Advancing Hantaan Virus Research: Superior Protection with Antigen-Antibody Technology
2024-07-29 273

Hantaan virus

Hantavirus pulmonary syndrome (HPS) is a rare but potentially life-threatening viral illness transmitted to humans through exposure to the infected urine, droppings, or saliva of certain mice and rat species. The disease is caused by hantaviruses, which are single-stranded, enveloped, negative-sense RNA viruses belonging to the family Hantaviridae.

Hantaviruses can lead to severe diseases such as Hantavirus Pulmonary Syndrome (HPS). HPS is one of two potentially fatal syndromes of zoonotic origin caused by species of hantavirus. These include Black Creek Canal virus (BCCV), New York orthohantavirus (NYV), Monongahela virus (MGLV), Sin Nombre orthohantavirus (SNV), and certain other members of hantavirus genera that are native to the United States and Canada.

The hantavirus genome consists of small (S), medium (M), and large (L) segments, encoding three proteins: nucleocapsid (N), glycoprotein precursor (GPC), which is cleaved by host signal peptidase to form Gn and Gc, and RNA-dependent RNA polymerase L (RdRp).

Glycoprotein N (Gn, also known as G1) is receptor binding, membrane fusion and viral morphogenesis. Glycoprotein C (Gc, also konw as G2) forms homotetramers with Gn at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3.

Antibodies that bind Gn and Gc have neutralizing activity and provide lasting protection in vivo. They are two important targets to develop effective vaccines and generate neutralizing antibodies.

 

Hantaan virus

Figure 1 Schematic representation of Hantaan virus(viralzone)

Nucleocapsid (N) is encoded by S segment with a molecular weight of 50 kDa. It is required for virus replication. Antibodies targeting the nucleoprotein arise rapidly following infection, rendering them a useful biomarker for infection.

RNA-dependent RNA polymerase L (RdRp) which responsible for the replication and transcription of the viral RNA genome, is the largest protein encoded by hantaviruses which derived from the L segment. The RNA-dependent RNA polymerase L (RdRp) of hantaviruses is capable of recombining homologous RNA sequences and thus enables virus evolution via superinfection.

 

Protein
Catalog No. Product Name
YVV38401 Recombinant BCCV Gc/Glycoprotein C Protein, N-His
YVV38402 Recombinant BCCV Gn/Glycoprotein N Protein, N-His
YVV38501 Recombinant BCCV N/Nucleoprotein Protein, N-His
Monoclonal Antibody
Catalog No. Product Name
DVV38401 Research Grade Anti-Orthohantavirus puumalaense GP Antibody (ADI-42898)
DVV38402 Research Grade Anti-Orthohantavirus puumalaense GP Antibody (ADI-65533)
DVV38403 Research Grade Anti-Orthohantavirus puumalaense GP Antibody (ADI-65534)
RVV38401 Anti-Hantaan virus/HTNV GP Antibody (3G1)
RVV38402 Anti-Hantaan virus/HTNV GP Antibody (A5)
VVV38401 InVivoMAb Anti-Orthohantavirus puumalaense GP/Envelopment polyprotein Antibody (4G2)
VVV38402 InVivoMAb Anti-Hantaan virus Glycoprotein C/Gc Broad-Neutralizing Antibody (Iv0260)
VVV38403 InVivoMAb Anti-Hantaan virus Glycoprotein C/Gc Broad-Neutralizing Antibody (Iv0261)
Polyclonal Antibody
Catalog No. Product Name
PVV38401 Anti-BCCV Gc/Glycoprotein C Polyclonal Antibody
PVV38402 Anti-BCCV Gn/Glycoprotein N Polyclonal Antibody
PVV38501 Anti-BCCV N/Nucleoprotein Polyclonal Antibody

 

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