Affiliations
- Department of Cardiology, Liuzhou Municipal Liutie Central Hospital, Liuzhou City, China.
- Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
- Health Management Institute, the Second Medical Center, Chinese PLA General Hospital, Beijing, China.
- Senior Department of Cardiology, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
- Journal of Geriatric Cardiology Editorial Office, Chinese PLA General Hospital, Beijing, China.
PMID: 39028940 DOI: 10.1097/FJC.0000000000001613
Abstract
Background: Myocardial ischemia-reperfusion (MIR)-induced arrhythmia is a major cause of death in patients with cardiovascular diseases. Reduction of Cx43 is known to induce arrhythmias after MIR, but the underlying mechanism is unclear.
Methods: Gene expression analysis and patient samples were used to identify differentially expressed genes in MIR. The toxic effects of TNFSF14 on cardiomyocytes were investigated, and herbal extracts were screened for protective effects.
Results: TNFSF14 reduced Cx43 by stimulating LTβR, disrupting c-Myc-mediated Cx43 transcription. Valtrate reversed the effect by promoting LTβR glycosylation, protecting against arrhythmia.
Conclusion: Valtrate suppresses TNFSF14-induced reduction of Cx43, attenuating arrhythmia after MIR.
