Affiliations
- Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
PMID: 37376650 PMCID: PMC10301383 DOI: 10.3390/v15061351
Abstract
Background: The emergence of SARS-CoV-2 variants of concern (VOCs) has challenged the effectiveness of current COVID-19 vaccines. Booster doses are necessary to extend vaccine efficacy and enhance neutralization titers against these variants.
Methods: This study investigates the immune effects of mRNA vaccines based on the WT (prototypic strain) and omicron (B1.1.529) strains as booster doses in mice. With two-dose inactivated vaccine priming, mRNA boosters were evaluated for their ability to elevate IgG titers and cell-mediated immunity.
Results: Booster doses with mRNA vaccines improved immune protection against corresponding variants, but cross-protection against distinct strains remained limited.
Conclusion: The study reveals effective vaccination strategies against Omicron and future SARS-CoV-2 variants.
Keywords
SARS-CoV-2; VOCs; booster vaccines; mRNA vaccines.
