Affiliations
- College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China. zlzhang@whu.edu.cn.
PMID: 34676383 DOI: 10.1039/d1lc00646k
Abstract
Background: Among the various forms of cancer immunotherapy, cancer vaccines have gained attention due to their potential for eliciting sustained antitumor immune responses.
Results: This study reports a personalized gel-droplet monocyte vaccine (GEMA) derived from host blood. A microfluidic platform facilitates monocyte separation and encapsulation in alginate gel droplets, enhancing antigen uptake and producing CD8+T cells. A cocktail vaccine approach was demonstrated using anti-PD-1 antibodies, leading to enhanced antitumor efficacy in a 4T1 breast tumor model.
Conclusion: This study presents a unique strategy for vaccine production and a combination therapy approach, showing promise for personalized cancer vaccine development.
