Catalog No.
YXX00101
Expression system
E. coli
Species
Staphylococcus aureus
Protein length
Ala27-Asn319
Predicted molecular weight
35.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09616
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-hemolysin, hly, Alpha-HL, Alpha-toxin, hla
Staphylococcus aureus α-hemolysin induces DNA methylation changes in human Th1 cells., PMID:40498273
QDS pathoblockers target and lock α-hemolysin., PMID:40209674
Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections., PMID:40168998
Imaging oligomers of alpha-toxin (Hla) variants using high-speed AFM and neutralizing Hla hemolytic activity with their antisera., PMID:40147500
Sub-inhibitory concentrations of tigecycline could attenuate the virulence of Staphylococcus aureus by inhibiting the product of α-toxin., PMID:40105354
Brazilin reduces methicillin-resistant Staphylococcus aureus virulence and pathogenicity by decreasing the secretion of the α-hemolysin., PMID:40068293
Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis., PMID:39960341
Subminimum inhibitory concentrations of rifampicin attenuate methicillin-resistant staphylococcus aureus virulence by suppressing SaeRS two-component system and arginine metabolism-related pathways., PMID:39909365
Highly sensitive detection of Staphylococcus aureus α-hemolysin protein (Hla or α-toxin) by apta-qPCR., PMID:39742925
The ability of sarA to limit protease production plays a key role in the pathogenesis of Staphylococcus aureus osteomyelitis irrespective of the functional status of agr., PMID:39611695
Post-translational toxin modification by lactate controls Staphylococcus aureus virulence., PMID:39537625
Daphnetin weakened the pathogenicity of methicillin-resistant Staphylococcus aureus by inhibiting Sortase A and α-hemolysin., PMID:39424258
Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts., PMID:39412594
One-step copper deposition-induced signal amplification for multiplex bacterial infection diagnosis on a lateral flow immunoassay device., PMID:39406071
Berberine Inhibits the Inflammatory Response Induced by Staphylococcus aureus Isolated from Atopic Eczema Patients via the TNF-α/Inflammation/RAGE Pathways., PMID:39404402
Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination., PMID:39379345
High hemolytic activity in Staphylococcus aureus t1081/ST45 due to increased hla protein production and potential RNAIII-independent regulation., PMID:39322509
Crystal structure of exfoliative toxin D from Staphylococcus aureus., PMID:39276694
The role of male hormones in bacterial infections: enhancing Staphylococcus aureus virulence through testosterone-induced Agr activation., PMID:39261350
α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells., PMID:39240270
YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulation., PMID:39229975
Amyloid transformations of phenol soluble modulin α1 in Staphylococcus aureus and their modulation deploying a prenylated chalcone., PMID:39127763
Inhibitory effect of Jingfang mixture on Staphylococcus aureus α-hemolysin., PMID:39083107
Norwogonin aids in fighting MRSA-induced pneumonia by targeting agrAC to inhibit α-hemolysin production., PMID:38990361
Genomic analysis and identification of a novel superantigen, SargEY, in Staphylococcus argenteus isolated from atopic dermatitis lesions., PMID:38990001
A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection., PMID:38982056
α-Hemolysin-mediated endothelial injury contributes to the development of Staphylococcus aureus-induced dermonecrosis., PMID:38953668
Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin., PMID:38921752
Skin colonization by Staphylococcus aureus in hemodialysis patients with pruritus and the effect of Staphylococcus aureus-secreted α-toxin on filaggrin expression., PMID:38894607
G protein-coupled estrogen receptor agonist G-1 decreases ADAM10 levels and NLRP3-inflammasome component activation in response to Staphylococcus aureus alpha-hemolysin., PMID:38867416
OTULIN haploinsufficiency predisposes to environmentally directed inflammation., PMID:38827742
In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection., PMID:38822525
A High-Homology Region Provides the Possibility of Detecting β-Barrel Pore-Forming Toxins from Various Bacterial Species., PMID:38791367
Cytotoxic Staphylococcus aureus PSMα3 inhibits the aggregation of human insulin in vitro., PMID:38757742
N-Formylation modifies membrane damage associated with PSMα3 interfacial fibrillation., PMID:38689531
Eliminating extracellular autoinducing peptide signals inhibits the Staphylococcus aureus quorum sensing agr system., PMID:38615572
Facile construction of sandwich ELISA based on double-nanobody for specific detection of α-hemolysin in food samples., PMID:38569370
The role of shear rates on amyloid formation from biofilm peptide phenol-soluble modulins., PMID:38549371
Construction of a Colorimetric and Fluorescence Dual-Mode Immunoassay Detection of Alpha-Hemolysin in Milk., PMID:38483346
Blood proteins self-assembly, staphylococcal enterotoxins-interaction, antibacterial synergistic activities of biogenic carbon/FeSO4/Cu/CuO nanocomposites modified with three antibiotics., PMID:38263198
Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation., PMID:38247172
Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection., PMID:38236641
LITAF protects against pore-forming protein-induced cell death by promoting membrane repair., PMID:38181093
The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction., PMID:38180978
A randomised, double-blind, placebo-controlled, first-in-human phase I study to characterise the safety, pharmacokinetics and immunogenicity of 9MW1411 in healthy Chinese subjects., PMID:38157918
Staphylococcus aureus activates NRLP3-dependent IL-1β secretion from human conjunctival goblet cells using α toxin and toll-like receptors 2 and 1., PMID:38089811
Inhibitory effect of theaflavin-3,3'-digallate can involve its binding to the "stem" domain of α-hemolysin of Staphylococcus aureus., PMID:37856196
Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis., PMID:37788087
Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock., PMID:37781371
Exploring the modulatory impact of isosakuranetin on Staphylococcus aureus: Inhibition of sortase A activity and α-haemolysin expression., PMID:37733916
For research use only. Not for human or drug use.
