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Research Grade Anti-Human TNFSF15/TL1A Antibody (TEV-48574)

Catalog #:   DHB54005 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB54005

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

TNFSF15, Vascular endothelial cell growth inhibitor, VEGI, TL1, TNF ligand-related molecule 1, Tumor necrosis factor ligand superfamily member 15

Concentration

1.95 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95150

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

TEV-48574

Data Image
References

TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential., PMID:40507829

Japanese Phase 1 Study for Global Development of Anti-TL1A Antibody PF-06480605: A Randomized, Placebo-Controlled, Single-Ascending Dose Study., PMID:40065559

TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414

Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis., PMID:39321363

Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717

Antibodies Targeting the Tumor Necrosis Factor-Like Ligand 1A in Inflammatory Bowel Disease: A New Kid on the (Biologics) Block?, PMID:39068930

Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice., PMID:38839915

TL1A inhibition for inflammatory bowel disease treatment: From inflammation to fibrosis., PMID:38574740

Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis., PMID:38348035

Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy., PMID:37337107

Protective efficacy induced by Eimeria maxima rhomboid-like protein 1 against homologous infection., PMID:36686197

Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes., PMID:34868046

A novel 10-gene immune-related lncRNA signature model for the prognosis of colorectal cancer., PMID:34814366

Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis., PMID:34257516

The relationship between TNF-like protein 1A and coronary artery aneurysms in children with Kawasaki disease., PMID:34232416

TL1A (TNFSF15) genotype affects the long-term therapeutic outcomes of anti-TNFα antibodies for Crohn's disease patients., PMID:33319044

Design, development, and evaluation of the efficacy of a nucleic acid-free version of a bacterial ghost candidate vaccine against avian pathogenic E. coli (APEC) O78:K80 serotype., PMID:33298146

Signaling in TNFSF15-mediated Suppression of VEGF Production in Endothelial Cells., PMID:33185864

TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses., PMID:33177161

Bevacizumab-Conjugated Quantum Dots: In Vitro Antiangiogenic Potential and Biosafety in Rat Retina., PMID:32522096

Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF., PMID:32381123

Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps., PMID:31641233

Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease., PMID:31379829

Association of Tumor Necrosis Like factor 1 A (TL1A) and its Decoy Receptor (DcR3) with The Disease Activity and Autoantibody Production in Rheumatoid Arthritis Patients., PMID:31332995

TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion., PMID:31176785

TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity., PMID:30972074

A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies., PMID:30617301

Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease., PMID:30295722

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease., PMID:30199539

Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities., PMID:30065306

TNFSF15 is likely a susceptibility gene for systemic lupus erythematosus., PMID:29803925

An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease., PMID:29436901

TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice., PMID:29254800

Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction., PMID:29135326

DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression., PMID:28560426

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease., PMID:28400196

Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation., PMID:28219835

TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals., PMID:27589684

Serum decoy receptor 3 levels are associated with the disease activity of MPO-ANCA-associated renal vasculitis., PMID:27251675

Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts., PMID:26956410

Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia., PMID:26393680

Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation., PMID:26099067

Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells., PMID:26096340

Effects of dietary selenium on host response to necrotic enteritis in young broilers., PMID:25575447

Dietary sodium selenite affects host intestinal and systemic immune response and disease susceptibility to necrotic enteritis in commercial broilers., PMID:25387235

Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis., PMID:25161149

Effects of salinomycin and Bacillus subtilis on growth performance and immune responses in broiler chickens., PMID:25135491

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis., PMID:24850426

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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Research Grade Anti-Human TNFSF15/TL1A Antibody (TEV-48574) [DHB54005]
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