Catalog No.
YXX09501
Expression system
E. coli
Species
Porphyromonas gingivalis
Protein length
Asp229-Pro683
Predicted molecular weight
52.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q51817
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lys-gingipain W83, 3.4.22.47, Lysine specific cysteine protease, Lysine-specific cysteine proteinase, Porphypain, PrtK48, Lys-gingipain catalytic subunit, 39 kDa adhesin, PrtK39, 15 kDa adhesin, PrtK15, 44 kDa adhesin, PrtK44, kgp, prtK, prtP
The Porphyromonas gingivalis RNA-binding protein is required for growth in high levels of zinc and persistence with host cells., PMID:40444155
Porphyromonas gingivalis gingipain potentially activates influenza A virus infectivity through proteolytic cleavage of viral hemagglutinin., PMID:39793895
Exploring the interplay between Porphyromonas gingivalis KGP gingipain, herpes virus MicroRNA-6, and Icp4 transcript in periodontitis: Computational and clinical insights., PMID:39480863
First crystal structure of the DUF2436 domain of virulence proteins from Porphyromonas gingivalis., PMID:39325582
Epimedium polysaccharides mitigates Porphyromonas gingivalis-exacerbated intestinal inflammation by suppressing the Th17 pathway and modulating the gut microbiota., PMID:39098669
Porphyromonas gingivalis virulence factors induce toxic effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective strategy., PMID:39033880
Antibacterial activity of corydalis saxicola bunting total alkaloids against Porphyromonas gingivalis in vitro., PMID:38629885
Microcontact-Imprinted Optical Sensors for Virulence Factors of Periodontal Disease., PMID:37151489
Impacts of Porphyromonas gingivalis periodontitis on rheumatoid arthritis autoimmunity., PMID:37098654
Interplay between Porphyromonas gingivalis Hemophore-Like Protein HmuY and Kgp/RgpA Gingipains Plays a Superior Role in Heme Supply., PMID:36752645
High glucose levels contribute to vascular fibrosis via the activation of the endothelial-to-mesenchymal transition in periodontitis., PMID:36537563
Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel Against Porphyromonas gingivalis., PMID:35663901
Molecular basis for avirulence of spontaneous variants of Porphyromonas gingivalis: Genomic analysis of strains W50, BE1 and BR1., PMID:35622827
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis., PMID:35491845
[Computer simulation of molecular docking between methylene blue and some proteins of Porphyromonas gingivalis]., PMID:35165464
Porphyromonas gingivalis Gingipains Induce Cyclooxygenase-2 Expression and Prostaglandin E2 Production via ERK1/2-Activated AP-1 (c-Jun/c-Fos) and IKK/NF-κB p65 Cascades., PMID:35110422
Kgp DNA Vaccine Prevents Experimental Periodontitis., PMID:34918502
Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells., PMID:34823251
Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion., PMID:34569151
Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet-activating factor receptor., PMID:33792027
Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts and Porphyromonas gingivalis., PMID:33445998
Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells., PMID:33332733
Construction and characterization of the PGN_0296 mutant of Porphyromonas gingivalis., PMID:33038516
Enzymatic Characteristics and Activities of Gingipains from Porphyromonas gingivalis., PMID:32815131
Identification and Modification of Porphyromonas gingivalis Cysteine Protease, Gingipain, Ideal for Screening Periodontitis., PMID:32582160
Thymoquinone inhibits biofilm formation and virulence properties of periodontal bacteria., PMID:32416351
Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis - Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva., PMID:32411104
Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis., PMID:32279229
Novel synthetic peptide derived from Porphyromonas gingivalis Lys-gingipain detects IgG-mediated host response in periodontitis., PMID:31838319
Construction and Characterization of a PGN_0297 Mutant of Porphyromonas gingivalis: Evidence of the Contribution of PGN_0297 to Gingipain Activity., PMID:31439954
Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis., PMID:31212040
PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains., PMID:31185896
Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor., PMID:30894633
Production of interferon-gamma, interleukin-6, and interleukin-1β by human peripheral blood mononuclear cells stimulated with novel lys-gingipain synthetic peptides., PMID:30868592
Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease., PMID:30861212
In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors., PMID:30859419
PGN_0297 is an essential component of the type IX secretion system (T9SS) in Porphyromonas gingivalis: Tn-seq analysis for exhaustive identification of T9SS-related genes., PMID:30599082
Role of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalis., PMID:30249709
Porphyromonas gingivalis Gingipains Display Transpeptidation Activity., PMID:29984580
[Association of fimA genotype to kgp genotype in Porphyromonas gingivalis from infected root canals of primary apical periodontitis]., PMID:29972959
Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ., PMID:29914927
Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14., PMID:29504253
Lipoprotein modifications by gingipains of Porphyromonas gingivalis., PMID:29341140
Effect of extracytoplasmic function sigma factors on autoaggregation, hemagglutination, and cell surface properties of Porphyromonas gingivalis., PMID:28931045
Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice., PMID:28924232
PorV is an Outer Membrane Shuttle Protein for the Type IX Secretion System., PMID:28821836
Differences in survival, virulence and biofilm formation between sialidase-deficient and W83 wild-type Porphyromonas gingivalis strains under stressful environmental conditions., PMID:28821225
Proteolytic effects of gingipains on trefoil factor family peptides., PMID:28726036
PKC, ERK/p38 MAP kinases and NF-κB targeted signalling play a role in the expression and release of IL-1β and CXCL8 in Porphyromonas gingivalis-infected THP1 cells., PMID:28493507
A Sialidase-Deficient Porphyromonas gingivalis Mutant Strain Induces Less Interleukin-1β and Tumor Necrosis Factor-α in Epi4 Cells Than W83 Strain Through Regulation of c-Jun N-Terminal Kinase Pathway., PMID:28362225
For research use only. Not for human or drug use.
