Catalog No.
VHB94601
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
Interferon alpha-2, IFN-alpha-2, Interferon alpha-A, LeIF A, IFNA2,IFN-Alpha, IFNA2A, IFNA2B, IFNA2C, Interferon alpha-1/13, IFN-alpha-1/13, Interferon alpha-D, LeIF D, IFNA1, IFNA13, IFN-α4, IFN-α5, IFN-α6, IFN-α7, IFN-α8, IFN-αl0, IFN-α14, IFN-α16, IFN-α17, IFN-α21
Concentration
3.53 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01563
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0001
Profiling type I and II interferon responses reveals distinct subgroups of pediatric patients with autoinflammatory disorders., PMID:40242151
Swine IFN cocktail can reduce mortality and lessen the tissue injury caused by African swine-fever-virus-infected piglets., PMID:39691698
Immunogenic Consideration of a Designed Polypeptide Against Brucellosis Compared to RB51: An In Vivo Study., PMID:39606679
Preliminary Study on Type I Interferon as a Mucosal Adjuvant for Human Respiratory Syncytial Virus F Protein., PMID:39591199
Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo., PMID:38685487
Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients., PMID:38310443
An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes., PMID:37994664
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques., PMID:37506197
Identification of a Tumor Cell Associated Type I IFN Resistance Gene Expression Signature of Human Melanoma, the Components of Which Have a Predictive Potential for Immunotherapy., PMID:35269844
Alterations in Saliva and Plasma Cytokine Concentrations During Long-Duration Spaceflight., PMID:34504500
In vivo and in vitro Evaluation of Cytokine Expression Profiles During Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection., PMID:34045884
Pharmacokinetics Versus In Vitro Antiproliferative Potency to Design a Novel Hyperglycosylated hIFN-α2 Biobetter., PMID:33443683
CXCR3A promotes the secretion of the antifibrotic decoy receptor sIL-13Rα2 by pulmonary fibroblasts., PMID:33026833
Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling., PMID:32333814
Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities., PMID:31826721
Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation., PMID:31628525
Zika Virus Infects Trabecular Meshwork and Causes Trabeculitis and Glaucomatous Pathology in Mouse Eyes., PMID:31068433
Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile., PMID:30952679
H5N1 Influenza a Virus Replicates Productively in Pancreatic Cells and Induces Apoptosis and Pro-Inflammatory Cytokine Response., PMID:30460207
Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination., PMID:29569714
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals., PMID:29146976
Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice., PMID:28428709
Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway., PMID:28127293
Glycosylation and antiproliferative activity of hyperglycosylated IFN-α2 potentiate HEK293 cells as biofactories., PMID:27867113
Distinctive downmodulation of plasmacytoid dendritic cell functions by vitamin D3 analogue calcipotriol., PMID:27342039
Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo., PMID:27099312
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant., PMID:27081760
MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections., PMID:26299622
Increased Frequency of CD49b/LAG-3(+) Type 1 Regulatory T Cells in HIV-Infected Individuals., PMID:26192268
Therapeutic alpha-interferons protein: structure, production, and biosimilar., PMID:24785737
Central role of interferon-beta in thymic events leading to myasthenia gravis., PMID:24393484
Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile., PMID:23408841
Novel CD8+ T cell-based vaccine stimulates Gp120-specific CTL responses leading to therapeutic and long-term immunity in transgenic HLA-A2 mice., PMID:22484292
TLR9 and TLR7 agonists mediate distinct type I IFN responses in humans and nonhuman primates in vitro and in vivo., PMID:22058422
Unique Cytokine/Chemokine Signatures for HIV-1 and HCV Mono-infection versus Co-infection as Determined by the Luminex® Analyses., PMID:21866203
Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts., PMID:21357681
Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice., PMID:21349838
Double-stranded RNA- and CpG DNA-induced immune responses in Atlantic salmon: comparison and synergies., PMID:18602433
Distinct signature type I interferon responses are determined by the infecting virus and the target cell., PMID:18572754
Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10., PMID:18569073
Four novel ULBP splice variants are ligands for human NKG2D., PMID:18544572
Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus., PMID:18466972
Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination., PMID:18400516
17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic cells., PMID:18209037
Enhanced circulating half-life and antitumor activity of a site-specific pegylated interferon-alpha protein therapeutic., PMID:18020402
Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets., PMID:17609379
The effects of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on T-cell-related cytokine production in vitro and in vivo., PMID:16780833
Inhibition of collagen gene expression by interferon-gamma: novel role of the CCAAT/enhancer binding protein beta (C/EBPbeta)., PMID:16331681
Carbohydrate composition of meningococcal lipopolysaccharide modulates the interaction of Neisseria meningitidis with human dendritic cells., PMID:16098219
Autoregulatory role of interleukin-10 in hepatitis C patients treated with IFN-alpha., PMID:15626155
For research use only. Not for human or drug use.
