Catalog No.
EHJ63001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Gly208
Predicted molecular weight
47.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NPF0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FDC-SM-8D6, FDC-signaling molecule 8D6, CD320, TCblR, 8D6 antigen, 8D6A, Transcobalamin receptor, CD320 antigen
Unveiling the hidden syndrome: The enigma of anti-transcobalamin receptor autoantibodies., PMID:40280282
Cobalamin Status Among Patients with Fetal Alcohol Spectrum Disorder (FASD)-A Preliminary Study., PMID:39940267
O-glycosylation is essential for cell surface expression of the transcobalamin receptor CD320., PMID:39551142
Proteomic and transcriptomic analyses identify apo-transcobalamin-II as a biomarker of overall survival in osteosarcoma., PMID:39493449
Single-Cell Meta-Analysis Uncovers the Pancreatic Endothelial Cell Transcriptomic Signature and Reveals a Key Role for NKX2-3 in PLVAP Expression., PMID:39445426
TCBIR/CD320: a potential therapeutic target upregulated in endothelial cells and associated with immune cell infiltration in liver hepatocellular carcinoma., PMID:38955924
Coexistence of systemic sclerosis and cryopyrin-associated periodic syndrome., PMID:38940218
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency., PMID:38924428
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis., PMID:38064339
Altered expression of nutrient transporters in syncytiotrophoblast membranes in preeclampsia placentae., PMID:37421872
Transcobalamin receptor gene polymorphisms and mutation in an elderly population., PMID:37202078
A phenotype driven integrative framework uncovers molecular mechanisms of a rare hereditary thrombophilia., PMID:37098010
Six immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation., PMID:36959615
Cyanocobalamin promotes muscle development through the TGF-β signaling pathway., PMID:36408829
Residues L55 and W69 of Tva Mediate Entry of Subgroup A Avian Leukosis Virus., PMID:36069550
Hijacking the intrinsic vitamin B12 pathway for the oral delivery of nanoparticles, resulting in enhanced in vivo anti-leishmanial activity., PMID:36017751
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route., PMID:35218573
Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene., PMID:35107211
CD320 expression and apical membrane targeting in renal and intestinal epithelial cells., PMID:34998874
Vitamin B12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions., PMID:34291881
Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter., PMID:33803025
Identification of a novel mechanism for meso-tetra (4-carboxyphenyl) porphyrin (TCPP) uptake in cancer cells., PMID:33629776
Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer., PMID:33545873
A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells., PMID:33136001
Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis., PMID:33081847
Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B12 Deficiency., PMID:33078371
Cellular uptake of vitamin B12: Role and fate of TCblR/CD320, the transcobalamin receptor., PMID:32898552
3'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women., PMID:32498429
Changes in whey proteome with lactation stage and parity in dairy cows using a label-free proteomics approach., PMID:31955735
Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung., PMID:31678655
N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia., PMID:30734924
Vitamin B12-conjugated sericin micelles for targeting CD320-overexpressed gastric cancer and reversing drug resistance., PMID:30328369
Neuropathology of vitamin B12 deficiency in the Cd320-/- mouse., PMID:30303736
Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet., PMID:30124850
Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR., PMID:30016500
Transcobalamin receptor defect: Identification of two new cases through positive newborn screening for propionic/methylmalonic aciduria and long-term outcome., PMID:29663633
89Zr-Cobalamin PET Tracer: Synthesis, Cellular Uptake, and Use for Tumor Imaging., PMID:29104950
Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse., PMID:28545069
The soluble transcobalamin receptor (sCD320) in relation to Alzheimer's disease and cognitive scores., PMID:28486088
Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin., PMID:28351841
First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk., PMID:27700208
Structural basis of transcobalamin recognition by human CD320 receptor., PMID:27411955
The effects of intrathecal rituximab on biomarkers in multiple sclerosis., PMID:27063622
The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta., PMID:26205293
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population., PMID:25948668
Vitamin B₁₂ and its binding proteins in hepatocellular carcinoma and chronic liver diseases., PMID:24958254
Transcobalamin derived from bovine milk stimulates apical uptake of vitamin B12 into human intestinal epithelial cells., PMID:24913691
Clinicopathologic comparison of plasmablastic lymphoma in HIV-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases., PMID:24832164
Investigation of a vitamin B12 conjugate as a PET imaging probe., PMID:24753453
Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion., PMID:24750446
For research use only. Not for human or drug use.
