Anti-K63-linked Polyubiquitin Antibody (SAA0330)

Catalog No.

RHC59303

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

UBC, Polyubiquitin-C, Ubiquitin

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P0CG48

Applications

ELISA, IHC, IF, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA0330

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness., PMID:40223186

Ubiquitin-specific protease 13 regulates FcεRI-mediated mast cell activation and allergic inflammation via SYK protein modulation., PMID:40139593

Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2., PMID:38227684

Epitope identification of a Lys63 linkage ubiquitin antibody by mass spectrometric epitope excision and extraction approaches., PMID:37724023

Chemically labeled ThUBD permits rapid and super-sensitive imaging of polyubiquitination signals., PMID:35797714

Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-κB Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains., PMID:33717069

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus., PMID:32641828

Specific and Unbiased Detection of Polyubiquitination via a Sensitive Non-Antibody Approach., PMID:31820937

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling., PMID:31585000

Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury., PMID:30013035

Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination., PMID:29746822

Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as Substrate., PMID:28573163

Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma., PMID:27070702

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation., PMID:26285145

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21., PMID:26150489

Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling., PMID:26033541

Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling., PMID:25774694

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism., PMID:25484089

Analysis of SHPRH functions in DNA repair and immunoglobulin diversification., PMID:25311267

IKK regulates the deubiquitinase CYLD at the postsynaptic density., PMID:24928390

Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis., PMID:24610907

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination., PMID:24023840

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes., PMID:23690480

Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation., PMID:22350886

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals., PMID:21048196

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody., PMID:20655260

ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination., PMID:20406983

K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44., PMID:20402667

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin., PMID:19091944

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies., PMID:18724939

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