Anti-SPRY2 Polyclonal Antibody

Catalog No.

PHA72001

Species reactivity

Human, Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SPRY2 (Ser116-Thr305).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Spry-2,SPRY2,Protein sprouty homolog 2

Purification

Purified by antigen affinity column.

Accession

O43597

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

MicroRNA-21-5p participates in IgA nephropathy by driving T helper cell polarization., PMID:31863364

Spred negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation., PMID:30290165

Effect of FGF2 on the activity of SPRYs/DUSP6/ERK signaling pathway in endometrial glandular epithelial cells of endometriosis., PMID:29630097

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred., PMID:29501879

Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura., PMID:29497996

Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways., PMID:27415760

Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling., PMID:27277891

Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL., PMID:26809508

Pathways driving the endocytosis of mutant and wild-type EGFR in cancer., PMID:25594057

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer., PMID:23624922

Sprouty genes function in suppression of prostate tumorigenesis., PMID:23150596

Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung., PMID:22236546

3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM., PMID:21998699

Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy., PMID:21909357

Activation of unfolded protein response in transgenic mouse lenses., PMID:21310900

The elusive role of the SPRY2 domain in RyR1., PMID:21239886

Sprouty2 downregulates angiogenesis during mouse skin wound healing., PMID:21076020

Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells., PMID:20624167

A novel role of Sprouty 2 in regulating cellular apoptosis., PMID:18070883

Regulator of epidermal growth factor signaling: Sprouty., PMID:16780213

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia., PMID:15937482

[Angiogenic growth factors in rheumatoid arthritis]., PMID:15799344

Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice., PMID:15505059

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