Catalog No.
DHC24401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
HL-1, ASGP-R 1, Asialoglycoprotein receptor 1, CLEC4H1, ASGR1, C-type lectin domain family 4 member H1, ASGPR 1, Hepatic lectin H1
Concentration
2.6 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07306
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AMG-529, AMG 529, AMG529
Clone ID
AMG 529
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D., PMID:39791910
Detection of γ-OHPdG in Circulating Tumor Cells of Patients With Hepatocellular Carcinoma as a Potential Prognostic Biomarker of Recurrence., PMID:39280920
Rapid depletion of "catch-and-release" anti-ASGR1 antibody in vivo., PMID:39051531
Targeted protein degradation systems to enhance Wnt signaling., PMID:38847394
The use of human iPSC-derived alveolar organoids to explore SARS-CoV-2 variant infections and host responses., PMID:38572923
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes., PMID:38355848
Analysis of SARS-CoV-2 Variant-Specific Serum Antibody Post-Vaccination Utilizing Immortalized Human Hepatocyte-Like Cells (HLC) to Assess Development of Immunity., PMID:38078048
ACE2-Independent Alternative Receptors for SARS-CoV-2., PMID:36423144
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion., PMID:35922515
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2., PMID:34837059
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2., PMID:34048708
Binding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein Receptor on Human Primary Hepatocytes and Immortalized Hepatocyte-Like Cells by Confocal Analysis., PMID:33883951
Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis., PMID:31497744
A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance., PMID:29282218
The role of sialic acids in the immune recognition of xenografts., PMID:29057592
Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2., PMID:27155063
Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers., PMID:26906939
Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion., PMID:25675194
ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro., PMID:21848542
A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes., PMID:20886072
[Preparation and identification of polyclonal antibody against protein H1b: the variant of major subunit of human ASGPR]., PMID:19811742
For research use only. Not for human or drug use.
