Research Grade Spesolimab (DHJ72801)

Catalog No.

DHJ72801

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

FIL1D, Interleukin-1 family member 5, IL-36Ra, IL1HY1, Interleukin-36 receptor antagonist protein, IL1RP3, IL-1RP3, IL-1ra homolog 1, Interleukin-1-like protein 1, IL-1-related protein 3, IL1L1, Interleukin-1 HY1, IL-1HY1, Interleukin-1 delta, FIL1 delta, IL-1 delta, IL-1L1, Interleukin-1 receptor antagonist homolog 1, IL36RN, IL1F5, IL-1F5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UBH0

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

BI 655130, BI655130, MAB92,CAS: 2097104-58-8

Clone ID

Spesolimab

Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendations, PMID: 32884319

Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease, PMID: 33919434

Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis, PMID: 30855749

Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study, PMID: 33661508

Spesolimab: A Novel Treatment for Pustular Psoriasis, PMID: 32208020

Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare, PMID: 33785490

Target molecules for future hidradenitis suppurativa treatment, PMID: 34085329

The interleukin-1 family cytokines in psoriasis: pathogenetic role and therapeutic perspectives, PMID: 33538202

Document Download

Research Grade Spesolimab.pdf