Catalog No.
DHC15802
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05231
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
COR-001, CAS: 2226654-05-1
Clone ID
Ziltivekimab
From RESCUE to ZEUS: will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction?, PMID: 34352102
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial, PMID: 34015342
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease, PMID: 33998272
Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial, PMID: 33272965
Seeking and treating inflammation in ischaemic heart disease: are we ready?, PMID:40248283
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment., PMID:40055964
"Anti-inflammatory Therapies in Atherosclerosis - Where are we going?"., PMID:39699771
Ziltivekimab for anemia and atherosclerosis in chronic kidney disease: a new hope?, PMID:39453604
Relationship Between Cardiac Structure and Function With Renal Function Trajectory and Outcomes in Patients With Heart Failure: Insights From the PARAGON-HF Trial., PMID:39212045
Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review., PMID:39031302
Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease: A systematic review and meta-analysis., PMID:38634217
C-reactive protein, pharmacological treatments and diet: how to target your inflammatory burden., PMID:38277208
Effect of Ziltivekimab on Determinants of Hemoglobin in Patients with CKD Stage 3-5: An Analysis of a Randomized Trial (RESCUE)., PMID:38088558
An Update on Inflammation in Atherosclerosis: How to Effectively Treat Residual Risk., PMID:37716836
Efficacy and safety of interleukin-6 inhibition with ziltivekimab in patients at high risk of atherosclerotic events in Japan (RESCUE-2): A randomized, double-blind, placebo-controlled, phase 2 trial., PMID:37211246
Innate Immunity System in Patients With Cardiovascular and Kidney Disease., PMID:37053283
Association of Interleukin 6 Inhibition With Ziltivekimab and the Neutrophil-Lymphocyte Ratio: A Secondary Analysis of the RESCUE Clinical Trial., PMID:36449307
Targeting the residual cardiovascular risk by specific anti-inflammatory interventions as a therapeutic strategy in atherosclerosis., PMID:35257900
Anti-inflammatory therapy in ischaemic heart disease: from canakinumab to colchicine., PMID:34650351
The role and transformative potential of IL-19 in atherosclerosis., PMID:34600839
From RESCUE to ZEUS: will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction?, PMID:34352102
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial., PMID:34015342
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease., PMID:33998272
Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial., PMID:33272965
A Phase 1 Randomized Dose-Escalation Study of a Human Monoclonal Antibody to IL-6 in CKD., PMID:35373026
For research use only. Not for human or drug use.
