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Research Grade Anti-Human CD226/DNAM-1 Antibody (lilly01)

Catalog #:   DHH18901 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG2
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHH18901

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2

Clonality

Monoclonal

Target

DNAX accessory molecule 1, DNAM-1, DNAM1, CD226 antigen, CD226

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15762

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

lilly01

Data Image
References

Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407

Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320

T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy., PMID:40294684

Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters., PMID:40027624

Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor microenvironment., PMID:40010766

Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma., PMID:39904787

CD226 + adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism., PMID:39677815

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function., PMID:39636437

Salvianolic acid B improves the microcirculation in a mouse model of sepsis through a mechanism involving the platelet receptor CD226., PMID:39443080

Integrated Transcriptomic Analysis Reveals Reciprocal Interactions between SARS-CoV-2 Infection and Multi-Organ Dysfunction, Especially the Correlation of Renal Failure and COVID-19., PMID:39202702

Clinical response and pathway-specific correlates following TIGIT-LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial., PMID:39187595

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function., PMID:39071293

A novel enzyme-linked immunosorbent assay tool to evaluate plasma soluble CD226 in primary Sjögren's syndrome., PMID:38768695

Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells., PMID:38635895

TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes., PMID:38533515

Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway., PMID:38386917

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy., PMID:38268493

Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity., PMID:38244725

Poliovirus receptor inhibition in breast cancer cells induces antitumor immunity via T cell activation., PMID:38187056

Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834

Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT., PMID:37675979

Combined Blockade of TIGIT and PD-L1 Enhances Anti-Neuroblastoma Efficacy of GD2-Directed Immunotherapy with Dinutuximab Beta., PMID:37444427

The apoptotic effects of NK-92 cells stimulated with an anti-CD226 antibody on MDA-MB-231 triple-negative breast cancer cells., PMID:37410214

The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity., PMID:36944702

CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene-induced atopic dermatitis., PMID:36938934

Costimulatory CD226 Signaling Regulates Proliferation of Memory-like NK Cells in Healthy Individuals with Latent Mycobacterium tuberculosis Infection., PMID:36361628

CD8+ and CD8- NKT Cells Exhibit Phenotypic Changes During Pregnancy., PMID:36102790

Biomarkers of disease activity in dermatomyositis., PMID:36082751

Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies., PMID:35998045

Inflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis., PMID:35860232

Emergence of the CD226 Axis in Cancer Immunotherapy., PMID:35812451

Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects., PMID:35812428

The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation., PMID:35733922

Pregnancy enables antibody protection against intracellular infection., PMID:35676476

Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas., PMID:35474089

Changes in the natural killer cell repertoire and function induced by the cancer immune adjuvant candidate IMMUNEPOTENT-CRP., PMID:35381435

TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy., PMID:35379739

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses., PMID:35263569

Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy., PMID:34888847

Immune checkpoint molecule TIGIT manipulates T cell dysfunction in septic patients., PMID:34653731

Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus., PMID:34373559

Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus., PMID:34367178

TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer., PMID:34367161

Cytokine-enhanced cytolytic activity of exosomes from NK Cells., PMID:34316033

Suppression of Th1 and Th17 Proinflammatory Cytokines and Upregulation of FOXP3 Expression by a Humanized Anti-DNAM-1 Monoclonal Antibody., PMID:33900821

Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients., PMID:33764509

TIGIT/CD226 Axis Regulates Anti-Tumor Immunity., PMID:33670993

Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1[*]0404 haplotype in rheumatoid arthritis., PMID:33427622

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis., PMID:33413573

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Anti-Human CD226/DNAM-1 Antibody (lilly01) [DHH18901]
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