Catalog No.
VHD38901
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
TNF-R2, TNFR-II, p80 TNF-alpha receptor, Etanercept, TNFBR, TBP-2, TBPII, Tumor necrosis factor receptor superfamily member 1B, CD120b, p75, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-RII, TNFR2, Tumor necrosis factor receptor type II
Concentration
1.08 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P20333
Applications
Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0309
The TNFRSF1B Connection: Implications for Androgenetic Alopecia Pathogenesis and Treatment., PMID:40343723
Enhancing cardiac repair post-myocardial infarction: a study on GATM/Gel hydrogel therapeutics., PMID:39937362
Ovalbumin-induced food allergy suppression via regulatory T cell expansion mediated by a TNFR2 agonist in mice., PMID:39489111
TNFR2 signaling in oligodendrocyte precursor cells suppresses their immune-inflammatory function and detrimental microglia activation in CNS demyelinating disease., PMID:39243989
Interferon-gamma signaling drives epithelial TNF-alpha receptor-2 expression during colonic tissue repair., PMID:39139033
The Oncogenic Role of TNFRSF12A in Colorectal Cancer and Pan-Cancer Bioinformatics Analysis., PMID:39118523
Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer., PMID:39033271
Combined Plasma Olink Proteomics and Transcriptomics Identifies CXCL1 and TNFRSF12A as Potential Predictive and Diagnostic Inflammatory Markers for Acute Kidney Injury., PMID:38472598
Blockade of sympathetic ganglia improves vascular dysfunction in septic shock., PMID:38457039
Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation., PMID:38341270
FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis., PMID:38173720
A novel single domain bispecific antibody targeting VEGF and TNF-α ameliorates rheumatoid arthritis., PMID:37992444
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells., PMID:37716622
Single-cell transcriptomics identify TNFRSF1B as a novel T-cell exhaustion marker for ovarian cancer., PMID:37712139
IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection., PMID:37628738
Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells., PMID:37612373
The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis., PMID:37553427
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond., PMID:37542139
Main active components of Ilex rotunda Thunb. protect against ulcerative colitis by restoring the intestinal mucosal barrier and modulating the cytokine-cytokine interaction pathways., PMID:37541404
Comprehensive chemical profiling of Bassia indica Wight. aerial parts extract using UPLC-ESI-MS/MS, and its antiparasitic activity in Trichinella spiralis infected mice: in silico supported in vivo study., PMID:37202749
Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis., PMID:37197892
Bioavailability of the tumor necrosis factor alpha/regulated on activation, normal T cell expressed and secreted (RANTES) biosystem inside the gestational sac during the pre-immune stages of embryo development., PMID:37067543
Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer., PMID:36946782
TNFR2 deficiency impairs the growth of mouse colon cancer., PMID:36923938
HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer., PMID:36867660
Bioactive fraction from Plumeria obtusa L. attenuates LPS-induced acute lung injury in mice and inflammation in RAW 264.7 macrophages: LC/QToF-MS and molecular docking., PMID:36773191
MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2., PMID:36319063
Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism., PMID:36293552
Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats., PMID:35986079
A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity., PMID:35769484
Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB) signaling pathway., PMID:35707851
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells., PMID:35676787
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases., PMID:35642214
Inflammation induces pro-NETotic neutrophils via TNFR2 signaling., PMID:35443164
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors., PMID:35260434
Targeting TNFR2 in Cancer: All Roads Lead to Rome., PMID:35251045
Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity., PMID:35251028
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown., PMID:35228654
The mineralocorticoid receptor blocker spironolactone lowers plasma interferon-γ and interleukin-6 in patients with type 2 diabetes and treatment-resistant hypertension., PMID:34843183
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells., PMID:34739338
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice., PMID:34565380
Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy., PMID:34559433
In vivo reprogramming of pathogenic lung TNFR2+ cDC2s by IFNβ inhibits HDM-induced asthma., PMID:34244314
Current Perspectives on the Role of TNF in Hematopoiesis Using Mice With Humanization of TNF/LT System., PMID:34054827
Collagen Peptides Derived from Sipunculus nudus Accelerate Wound Healing., PMID:33806637
Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander., PMID:33782090
A wake-like state in vitro induced by transmembrane TNF/soluble TNF receptor reverse signaling., PMID:33571627
Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus., PMID:33543485
TNF-TNFR2 Signal Plays a Decisive Role in the Activation of CD4+Foxp3+ Regulatory T Cells: Implications in the Treatment of Autoimmune Diseases and Cancer., PMID:33523452
Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway., PMID:33513343
For research use only. Not for human or drug use.
