Anti-Human SLC6A4/SERT Antibody (8B6)

Catalog No.

RHD96302

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

5HT transporter, 5HTT, SERT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4, HTT, SLC6A4

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P31645

Applications

Blocking, ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

8B6

Prenatal Opioid and Alcohol Exposures: Association with Altered Placental Serotonin Transporter Structure and/or Expression., PMID:39519122

Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism., PMID:33294225

A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression., PMID:31029013

TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis., PMID:29723540

The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice., PMID:28198447

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram., PMID:27929454

Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus., PMID:27819008

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease., PMID:26464486

Circulating tumour necrosis factor is highly correlated with brainstem serotonin transporter availability in humans., PMID:26255693

Induction of interleukin-1β by activated microglia is a prerequisite for immunologically induced fatigue., PMID:25040499

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation., PMID:24973209

Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders., PMID:24389572

Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling., PMID:24389360

3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors., PMID:23261423

Serotonin innervation of human basal ganglia., PMID:21375599

Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors., PMID:21329710

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects., PMID:20494921

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease., PMID:19825844

Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression., PMID:19747920

Resilience and vulnerability are dose-dependently related to neonatal stressors in mice., PMID:19632235

The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network., PMID:19270731

Monitoring mouse serotonin transporter internalization in stem cell-derived serotonergic neurons by confocal laser scanning microscopy., PMID:19121357

A function of huntingtin in guanine nucleotide exchange on Rab11., PMID:18845944

Dystrophic serotonergic axons in neurodegenerative diseases., PMID:18502405

Identification of candidate genes that influence sex hormone-dependent disease phenotypes in mouse lupus., PMID:18046341

Function, expression, and characterization of the serotonin transporter in the native human intestine., PMID:17991706

Raphe magnus nucleus is involved in ventilatory but not hypothermic response to CO2., PMID:17823301

Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models., PMID:17413322

At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner., PMID:17355243

Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells., PMID:16884969

Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease., PMID:16405500

(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane., PMID:15937150

Western blot analysis of human and rat serotonin transporter in platelets and brain using site-specific antibodies: evidence that transporter undergoes endoproteolytic cleavage., PMID:15936305

Postnatal expression of the serotonin transporter in auditory brainstem neurons., PMID:15886479

Receptors and transporter for serotonin in Merkel cell-nerve endings in the rat sinus hair follicle. An immunohistochemical study., PMID:15827375

Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test., PMID:15820524

Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra., PMID:15715653

Analysis of serotonin transporter in human platelets by immunoblotting using site-specific antibodies., PMID:15236602

Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin., PMID:15226315

GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat., PMID:14984406

Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats., PMID:14634717

Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporter., PMID:12781873

NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex., PMID:12498788

Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA)., PMID:12480182

Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide., PMID:12220580

Effects of chronic maternal ethanol exposure on hippocampal and striatal morphology in offspring., PMID:12105110

[Levels and molecular heterogeneity of serotonin transporter protein in platelets of patients with different mental diseases: a comparative analysis with the use of monoclonal and polyclonal antibodies]., PMID:11523428

Age-associated changes in the serotonergic system in rat superior colliculus and pretectum., PMID:11489352

Serotonin transporter in rat platelets. Level of protein expression underlies inherited differences in uptake kinetics., PMID:11411805

The state of the serotonin transporter protein in the platelets of patients with somatoform [correction of somatiform] disorders., PMID:11392354

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