Anti-AIM2 Polyclonal Antibody

Catalog No.

PHA32701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AIM2 (Met1-Lys342).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Absent in melanoma 2,Interferon-inducible protein AIM2,AIM2

Concentration

1.2 mg/ml

Purification

Purified by antigen affinity column.

Accession

O14862

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2 V617F clonal hematopoiesis-driven atherosclerosis., PMID:40501724

DNASE1L3-mediated PANoptosis enhances the efficacy of combination therapy for advanced hepatocellular carcinoma., PMID:39479454

Early divergent modulation of NLRP2's and NLRP3's inflammasome sensors vs. AIM2's one by signals from Aβ·Calcium-sensing receptor complexes in human astrocytes., PMID:39426463

Swaying the advantage: multifaceted functions of inflammasomes in adaptive immunity., PMID:38922787

Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease., PMID:38260617

Overexpressed CD44 is associated with B-cell activation via the HA-CD44-AIM2 pathway in lupus B cells., PMID:37499961

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk., PMID:37498674

Aberrant inflammasome activation as a driving force of human autoimmune skin disease., PMID:37325658

Immune Regulation by Cytosolic DNA Sensors in the Tumor Microenvironment., PMID:37046775

Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis., PMID:36988888

cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus., PMID:36591278

AIM2 as a putative target in acute kidney graft rejection., PMID:36248890

Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method., PMID:36169732

The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps., PMID:35608258

Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen., PMID:35465352

Novel immune-related signature based on immune cells for predicting prognosis and immunotherapy response in clear cell renal cell carcinoma., PMID:35441741

Could anakinra outmatch dexamethasone/tocilizumab in COVID-19?, PMID:35431536

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation., PMID:35385861

AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation., PMID:34521812

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release., PMID:34401873

Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis., PMID:34395445

The complex role of AIM2 in autoimmune diseases and cancers., PMID:34014039

Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics., PMID:33926787

Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain., PMID:33875472

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release., PMID:33758872

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis., PMID:33731931

Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871

Inflammasome Assays In Vitro and in Mouse Models., PMID:33017103

Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome., PMID:32171704

Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis., PMID:31604370

Cytomegalovirus Infection May Trigger Adult-Onset Still's Disease Onset or Relapses., PMID:31068953

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages., PMID:30290143

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism., PMID:30100261

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis., PMID:29915579

Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation., PMID:29686531

Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis., PMID:29648974

Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C., PMID:29295921

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection., PMID:28968459

Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis., PMID:27760209

Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells., PMID:27636895

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes., PMID:27365531

Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs., PMID:27231253

Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking., PMID:27221486

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation., PMID:27148820

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly., PMID:27069117

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus., PMID:27035940

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β., PMID:26515418

The regional function of cGAS/STING signal in multiple organs: One of culprit behind systemic lupus erythematosus?, PMID:26464144

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