Catalog No.
PHA20001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ISLR (Cys19-Phe428).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:100-1:500, WB: 1:1000 |
Target
ISLR,Immunoglobulin superfamily containing leucine-rich repeat protein
Concentration
1 mg/ml
Purification
Purified by antigen affinity column.
Accession
O14498
Form
Liquid
Storage buffer
PBS with 0.05% sodium azide
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)., PMID:9325048
Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression., PMID:10512678
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling., PMID:11832495
Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo., PMID:18848646
Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., PMID:26924503
A novel ISLR2-linked autosomal recessive syndrome of congenital hydrocephalus, arthrogryposis and abdominal distension., PMID:30483960
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy., PMID:30510196
Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., PMID:31221024
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., PMID:31439548
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling., PMID:32128839
ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway., PMID:32696215
Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., PMID:32705221
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., PMID:33197448
Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue., PMID:33760832
Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., PMID:33960573
ISLR affects colon cancer progression by regulating the epithelial-mesenchymal transition signaling pathway., PMID:34520435
Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer., PMID:34713300
Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma., PMID:35209871
CNN-LSTM Hybrid Real-Time IoT-Based Cognitive Approaches for ISLR with WebRTC: Auditory Impaired Assistive Technology., PMID:35237390
Silencing of immunoglobulin superfamily containing leucine-rich repeat inhibits gastric cancer cell growth and metastasis by regulating epithelial-mesenchymal transition., PMID:35653801
Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis., PMID:36077405
Toward harmonized interpretation of anticardiolipin and anti-β2-glycoprotein I antibody detection for diagnosis of antiphospholipid syndrome using defined level intervals and likelihood ratios: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies., PMID:38704123
Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity., PMID:38786060
Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., PMID:39136356
For research use only. Not for human or drug use.
