Anti-Mouse DKK1 Antibody (MOR04454)

Catalog No.

RMB48101

Species reactivity

Human, Mouse

Host species

Rat

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O54908

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

MOR04454

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway., PMID:40394415

Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression., PMID:40337977

Research Progress on the Influence of Novel Targeted Drugs for Osteoporosis on Glucose Metabolism., PMID:40149867

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364

Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions., PMID:40025612

Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer., PMID:39885132

Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis., PMID:39713389

Tumor cells induce neural DKK1 expression to promote MDSC infiltration and subsequent T cell suppression., PMID:39710089

CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression., PMID:39689859

Novel DNA Aptamers to Dickkopf-1 Protein and Their Application in Colorimetric Sandwich Assays for Target Detection in Patients with Axial Spondyloarthritis., PMID:39596285

Annexin A6 modulates the secretion of pro-inflammatory cytokines and exosomes via interaction with SNAP23 in triple negative breast cancer cells., PMID:39484394

DKN-01 in Combination With Tislelizumab and Chemotherapy as First-Line Therapy in Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: DisTinGuish., PMID:39432867

Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab., PMID:39417106

DKN-01 Suppresses Gastric Cancer Progression Through Activating cGAS-STING Pathway to Block Macrophage M2 Polarization., PMID:39352454

Genetic Variants in RANK and OPG Could Influence Disease Severity and Bone Remodeling in Patients with Early Arthritis., PMID:39337893

Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A and Catestatin with Serological and Inflammatory Markers in Rheumatoid Arthritis Patients., PMID:39337398

Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling., PMID:39118263

Targeting DKK1 enhances the antitumor activity of paclitaxel and alleviates chemotherapy-induced peripheral neuropathy in breast cancer., PMID:39085861

Enhancing motor functional recovery in spinal cord injury through pharmacological inhibition of Dickkopf-1 with BHQ880 antibody., PMID:38795645

New therapeutic target molecules for gastric and gastroesophageal junction cancer., PMID:38630383

Current and Future Biomarkers in Esophagogastric Adenocarcinoma., PMID:38280174

Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers., PMID:38267222

Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases., PMID:38168574

Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice., PMID:38152853

Inhibition of both sclerostin and DKK1 results in novel skull findings in the rat and non-human primate that is not observed with inhibition of sclerostin alone., PMID:38052372

Wnt pathway in bone: knowledge structure and hot spots from 1993 to 2022., PMID:38033331

Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata., PMID:37991164

Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway., PMID:37946278

Potential significance of changes in serum levels of IL-17, TNF-α and DKK-1 in the progression of the rheumatoid arthritis., PMID:37909152

Changes in bone turnover markers and bone modulators during abatacept treatment., PMID:37821541

Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury., PMID:37263344

Wnt Signaling Activation in Gingival Epithelial Cells and Macrophages of Experimental Periodontitis., PMID:37232780

Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured Bone: An Experimental Study in Nonhuman Primates., PMID:37159527

CKAP4 is a potential exosomal biomarker and therapeutic target for lung cancer., PMID:37057110

DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma., PMID:37001446

Multi-Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma., PMID:36987921

Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice., PMID:36891756

Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells., PMID:36765434

Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton., PMID:36465166

Pathophysiology and therapeutic advances in myeloma bone disease., PMID:36420171

Erosive arthritis in systemic lupus erythematosus: application of cluster analysis., PMID:36305362

A proof of concept for targeting the PrPC - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer., PMID:35962130

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01., PMID:35924447

RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease., PMID:35861833

Clinical Diagnostic Value of Dkk-1 Level in Ankylosing Spondylitis: Comparison of Test Systems Based on Aptamers and Antibodies., PMID:35852688

Pharmacological inhibition of DKK1 promotes spine fusion in an ovariectomized rat model., PMID:35688363

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice., PMID:35659360

Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report., PMID:35531363

Effects of Biological/Targeted Therapies on Bone Mineral Density in Inflammatory Arthritis., PMID:35456929

Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts., PMID:35455968

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