Catalog No.
FHC33330
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD41, ITGAB, GPIIb, ITGA2B, Platelet membrane glycoprotein IIb, GP2B, Integrin alpha-IIb, GPalpha IIb, GPIIIa, Integrin beta-3, CD61, ITGB3, Platelet membrane glycoprotein IIIa, GP3A, PAC-1
Concentration
1.75 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08514 & P05106
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
PAC-1
An αIIbβ3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the FcγIIa Receptor., PMID:40101235
Influence of sodium ferulate on neutrophil extracellular traps-platelet activation-mediated endothelial dysfunction in immune small vasculitis., PMID:39917008
Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2., PMID:39640769
Association between O-GlcNAc levels and platelet function in obese insulin-resistant subjects., PMID:39300054
Platelet transfusion enhances pro-aggregatory status shortly after coronary artery bypass grafting (CABG while modulating platelet pro-inflammatory state 1-week post-surgery., PMID:39121235
An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding., PMID:38968144
Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology., PMID:38940930
Off-target effect of high-dose sildenafil on adenosine 5'- diphosphate and collagen-induced platelet activation through mitogen-activated protein kinase pathway in treated BALB/C mice and in vitro experiments: A preliminary study., PMID:38808925
Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media., PMID:38534483
Feasibility and comparability of different platelet function tests in acute stroke with or without prior antiplatelet therapy., PMID:38410198
Targeting the PACAP-38 pathway is an emerging therapeutic strategy for migraine prevention., PMID:38337150
Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress., PMID:38112069
The effects of glucocorticoid plus intravenous immunoglobulin (IVIG) vs IVIG alone on platelet activation in children with Kawasaki disease., PMID:37661679
Future targets for migraine treatment beyond CGRP., PMID:37370051
A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia., PMID:36884296
Platelet Activation and Cytokine Release of Interleukin-8 and Interferon-Gamma-Induced Protein 10 after ChAdOx1 nCoV-19 Coronavirus Vaccine Injection., PMID:36851332
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies., PMID:36430275
Clot-targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis., PMID:35950914
Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel., PMID:35037555
Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation., PMID:35020670
Levels of procoagulant microparticles expressing phosphatidylserine contribute to bleeding phenotype in patients with inherited thrombocytopenia., PMID:34475331
Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study., PMID:34393518
Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination., PMID:34388849
Platelet reticulated forms, size indexes and functional activity. Interactions in healthy volunteers., PMID:34029503
Emerging Targets for Migraine Treatment., PMID:34003154
Difference in inflammation, atherosclerosis, and platelet activation between coronary artery aneurysm and coronary artery ectasia., PMID:33209413
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19., PMID:32887634
Small procoagulant platelets in diabetes type 2., PMID:32629151
Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)., PMID:32508559
Platelet hyperactivation in multiple myeloma is also evident in patients with premalignant monoclonal gammopathy of undetermined significance., PMID:32478420
Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia., PMID:32272276
Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae-The role of FcγRIIa and platelet factor 4/heparinantibodies., PMID:32237268
Acquired Glanzmann thrombasthenia associated with platelet desialylation., PMID:31869497
Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma., PMID:31326577
Altered activation of integrin ɑIIbβ3 on platelets irradiated with ultraviolet C from pathogen-reducing xenon flash., PMID:31105058
Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes., PMID:30978226
Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT., PMID:30929196
First description of an IgM monoclonal antibody causing αIIb β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia., PMID:30868743
Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa., PMID:30692520
Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study., PMID:30571484
Platelet activity and hypercoagulation in type 2 diabetes., PMID:30388964
A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies., PMID:30388316
Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins., PMID:30385858
A Proposed Role of Surfactant in Platelet Function and Treatment of Pulmonary Hemorrhage in Preterm and Term Infants., PMID:30343298
A preliminary study of platelet hyperactivity in the chronic indeterminate phase of Chagas' disease., PMID:33601755
PACAP38 and PAC1 receptor blockade: a new target for headache?, PMID:30088106
PACAP38 in human models of primary headaches., PMID:29453754
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets., PMID:29306729
Increased platelet activation occurs in cystic fibrosis patients and correlates to clinical status., PMID:29274562
Acute Impact of Different Exercise Modalities on Arterial and Platelet Function., PMID:29240651
For research use only. Not for human or drug use.
