Catalog No.
FMH10710
Species reactivity
Human, Mouse
Host species
Rat
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
ShhNC, Sonic hedgehog protein, Shh N-terminal processed signaling domains, SHH, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhN, ShhNp, HHG-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q62226
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
6D7
Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival., PMID:40461501
Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model., PMID:40456204
A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25., PMID:40369344
Immunohistochemical detection of 5-hydroxymethylcytosine as a prognostic biomarker in non-WNT/Non-SHH medulloblastomas., PMID:40325038
Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma., PMID:40303994
Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols., PMID:40292331
The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation., PMID:40277903
Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547
Sea Hare Hydrolysate Reduces PD-L1 Levels in Cancer Cells and Mitigates Rheumatoid Arthritis Ina Collagen-Induced Arthritis Mouse Model., PMID:39803276
Exome Sequencing of Chinese Patients With Anticitrullinated Protein Antibody-Positive Rheumatoid Arthritis in Singapore., PMID:39617413
Development of a ZRS Reporter System for the Newt (Cynops pyrrhogaster) During Terrestrial Limb Regeneration., PMID:39595071
Development and evaluation of two rapid lateral flow assays for on-site detection of African swine fever virus., PMID:39268541
Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine., PMID:39127736
Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response., PMID:39046874
Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC., PMID:38924756
Development of a dual immunochromatographic test strip to detect E2 and Erns antibodies against classical swine fever., PMID:38666258
Incidence of Hyper Progressive Disease in Combination Immunotherapy and Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Monotherapy for Unresectable Hepatocellular Carcinoma., PMID:38344443
Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice., PMID:38299355
MMP-2-mediated Scube2 degradation promotes blood-brain barrier disruption by blocking the interaction between astrocytes and endothelial cells via inhibiting Sonic hedgehog pathway during early cerebral ischemia., PMID:38148633
Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma., PMID:37627061
Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency., PMID:37596280
Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency., PMID:37527762
Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma., PMID:37471625
Brain and Spinal Cord Tumors of Embryonic Origin., PMID:37452947
Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma., PMID:37240278
SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches., PMID:37142671
[Study on in vitro differentiation of human adenoid-derived mesenchymal stem cells into olfactory sensory neurons]., PMID:36878502
Bothrops (Fer-de-lance) snakebites in the French departments of the Americas (Martinique and Guyana): Clinical and experimental studies and treatment by immunotherapy., PMID:36854042
Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024
Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models., PMID:36443837
CD155 is a putative therapeutic target in medulloblastoma., PMID:36301489
Selective targeting BMP2 and 4 in SMAD4 negative esophageal adenocarcinoma inhibits tumor growth and aggressiveness in preclinical models., PMID:35902550
Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma., PMID:35860588
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis., PMID:35806043
Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis., PMID:35682653
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants., PMID:35568025
Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas., PMID:35551459
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species., PMID:35505662
Health-related quality-of-life outcomes in patients with advanced renal cell carcinoma treated with lenvatinib plus pembrolizumab or everolimus versus sunitinib (CLEAR): a randomised, phase 3 study., PMID:35489363
Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques., PMID:35404959
B Cell Depletion and SARS-CoV-2 Vaccine Responses in Neuroimmunologic Patients., PMID:35067959
Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway., PMID:34946023
Macaque-human differences in SARS-CoV-2 Spike antibody response elicited by vaccination or infection., PMID:34909774
Medulloblastoma: Clinicopathological Correlates of SHH, WNT, and Non-WNT/SHH Molecular Subgroups Analysis and Prognostic Significance: Mono-Institutional Series., PMID:34751426
An H3F3A K27M-mutation in a sonic hedgehog medulloblastoma., PMID:34747078
SHH Expression Is Significantly Associated With Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma., PMID:34732409
Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease., PMID:34725405
Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G in the CSF: Clinical Implication of Testing and Association With Disability., PMID:34711644
Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS-FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity., PMID:34667115
Development and validation of a hedgehog heparin-binding assay for high-throughput screening., PMID:34434730
For research use only. Not for human or drug use.
